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Status |
Public on Sep 16, 2024 |
Title |
Integrative single-cell and spatial transcriptomic analyses identify a pathogenic cholangiocyte niche and TNFRSF12A as therapeutic target for biliary atresia |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing Other
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Summary |
We performed single cell 5' RNA sequencing, and B cell receptor and T cell receptor V(D)J sequencing analyses on liver biopsies of nine patients with biliary atresia and three patients with choledochal cyst at diagnosis to generate the liver cell atlas.
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Overall design |
Single cell 5' RNA sequencing and V(D)J sequencing analyses of liver biopsies from nine patients with biliary atresia and three patients with choledochal cyst were collected at the time of diagnosis. 10x Genomics Chromium Next GEM Single Cell 5' RNA-seq and single cell V(D)J sequencing.
**Submitter declares that the raw data have not been provided due to patient privacy concerns**
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Contributor(s) |
Luo Z |
Citation(s) |
39178365 |
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Submission date |
Jun 04, 2021 |
Last update date |
Sep 17, 2024 |
Contact name |
Zhenhua Luo |
E-mail(s) |
luozhh35@mail.sysu.edu.cn
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Organization name |
The First Affiliated Hospital, Sun Yat-sen University
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Street address |
Number 58, zhongshan er road, Yuexiu,
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City |
Guangzhou |
State/province |
Guangzhou |
ZIP/Postal code |
510080 |
Country |
China |
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Platforms (1) |
GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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Samples (36)
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Relations |
BioProject |
PRJNA735239 |