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| Status |
Public on Jun 09, 2021 |
| Title |
Quantitative Analysis of Erythroblast Transcriptomes in Control and NUP-17d Treatment Groups |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
NUP-17d (17d) is an effective inhibitor of Plek2 protein. NUP-17d treatment inhibits erythroblast proliferation, differentiation and enucleation in a dose-dependent manner via directly binding to Plek2 protein. To reveal the detailed involving mechanism of NUP-17d treatment, we performed RNA sequencing to analyze the gene expression profiles change in erythroblasts which were treated with NUP-17d or DMSO (NC) for 48 hours in the EPO induction culture system.
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| Overall design |
mRNA profiles of erythroblasts treated with NUP-17d or DMSO (NC) for 48 hours in the EPO induction culture system were generated by deep sequencing, in triplicate, using DNBseq SE50 RNA-Seq.
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| Contributor(s) |
Han X, Ji P |
| Citation(s) |
36719747 |
| |
| Submission date |
Jun 08, 2021 |
| Last update date |
Apr 04, 2023 |
| Contact name |
Xu Han |
| E-mail(s) |
xu.han@northwestern.edu
|
| Organization name |
Northwestern University
|
| Department |
Pathology
|
| Lab |
Peng Ji lab
|
| Street address |
303 E Chicago Avenue, Ward 3-240
|
| City |
Chicago |
| State/province |
Illinois |
| ZIP/Postal code |
60611 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA736071 |
| SRA |
SRP323249 |
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