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Status |
Public on Jan 10, 2022 |
Title |
RNA sequencing of Hoxb8 yolk sac- and bone marrow-derived |
Organism |
Mus musculus |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Progenitor cells of yolk sac and bone marrow origin were transduced with an estrogen receptor Hoxb8 fusion protein to generate stable cell lines. Macrophages were differentiated with M-CSF in the absence of estrogen, and then stimulated with IL-4 or LPS. Hoxb8 progenitor cells and differentiated macrophages were analyzed by RNA sequencing.
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Overall design |
RNA profile of YS vs. BM Hoxb8 cell lines (progenitors and differentiated macrophages - unstimulated/ IL4-/ LPS-treated for 5 hours
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Contributor(s) |
Schulz C, Elhag S, Stremmel C, Bonin M |
Citation(s) |
- Elhag S, Stremmel C, Zehrer A, Plocke J et al. Differences in Cell-Intrinsic Inflammatory Programs of Yolk Sac and Bone Marrow Macrophages. Cells 2021 Dec 17;10(12). PMID: 34944072
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Submission date |
Jun 08, 2021 |
Last update date |
Jan 10, 2022 |
Contact name |
Tobias Straub |
E-mail(s) |
tstraub@med.uni-muenchen.de
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Organization name |
LMU Munich
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Department |
Biomedical Center, Bioinformatics
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Street address |
Großhadener Str. 9
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City |
Martinsried |
ZIP/Postal code |
82152 |
Country |
Germany |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (24)
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GSM5364140 |
BM progenitors, untreated #1 |
GSM5364141 |
BM progenitors, untreated #2 |
GSM5364142 |
YS differentiated, IL4-treated #2 |
GSM5364143 |
BM progenitors, untreated #3 |
GSM5364144 |
YS differentiated, untreated #2 |
GSM5364145 |
YS differentiated, untreated #3 |
GSM5364146 |
YS differentiated, IL4-treated #3 |
GSM5364147 |
YS differentiated, LPS-treated #1 |
GSM5364148 |
BM differentiated, LPS-treated #1 |
GSM5364149 |
BM differentiated, untreated #2 |
GSM5364150 |
YS progenitors, untreated #1 |
GSM5364151 |
YS progenitors, untreated #2 |
GSM5364152 |
BM differentiated, IL4-treated #1 |
GSM5364153 |
BM differentiated, LPS-treated #2 |
GSM5364154 |
BM differentiated, IL4-treated #2 |
GSM5364155 |
YS differentiated, LPS-treated #2 |
GSM5364156 |
YS progenitors, untreated #3 |
GSM5364157 |
YS differentiated, LPS-treated #3 |
GSM5364158 |
BM differentiated, untreated #3 |
GSM5364159 |
BM differentiated, LPS-treated #3 |
GSM5364160 |
BM differentiated, IL4-treated #3 |
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Relations |
BioProject |
PRJNA736088 |
SRA |
SRP323261 |
Supplementary file |
Size |
Download |
File type/resource |
GSE176409_Raw_gene_counts_matrix.txt.gz |
798.2 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
Raw data are available in SRA |
Processed data are available on Series record |
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