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| Status |
Public on Jul 16, 2010 |
| Title |
Expression data from Ts1Cje and disomic C57BL/6 adult neurospheres |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Down syndrome is the most common form of genetic mental retardation. How Trisomy 21 causes mental retardation remains unclear and its effects on adult neurogenesis have not been addressed. To gain insight into the mechanisms causing mental retardation we used microarrays to investigate gene expression differences between Ts1Cje (a mouse model of Down syndrome) and C57BL/6 littermate control neurospheres. The neurospheres were generated from neural stem cells and progenitors isolated from the lateral walls of the lateral ventricles from adult mice.
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| Overall design |
RNA was extracted for hybridization to arrays from 3 pairs of Ts1Cje and disomic C57BL/6 littermate control 7-day old adult neurosphere cultures.
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| Contributor(s) |
Hewitt CA, Ling K, Merson TD, Simpson KM, Ritchie ME, King SL, Pritchard MA, Smyth GK, Thomas T, Scott HS, Voss AK |
| Citation(s) |
20661276 |
| |
| Submission date |
Aug 21, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Chelsee A Hewitt |
| E-mail(s) |
Chelsee.Hewitt@petermac.org
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| Phone |
+61 3 9656 3524
|
| Organization name |
The Peter MacCallum Cancer Centre
|
| Department |
Pathology
|
| Street address |
St Andrews Place
|
| City |
East Melbourne |
| State/province |
VIC |
| ZIP/Postal code |
3051 |
| Country |
Australia |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| GSM443577 |
C57BL/6 neurospheres, biological rep1 |
| GSM443578 |
Ts1Cje neurospheres, biological rep1 |
| GSM443579 |
C57BL/6 neurospheres, biological rep2 |
| GSM443580 |
Ts1Cje neurospheres, biological rep2 |
| GSM443581 |
C57BL/6 neurospheres, biological rep3 |
| GSM443582 |
Ts1Cje neurospheres, biological rep3 |
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| Relations |
| BioProject |
PRJNA118303 |
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