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Status |
Public on Jun 05, 2023 |
Title |
Profiling of a series of triple positive (CD10+BCL6+MUM1+) diffuse large B-cell lymphoma cases |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by array Genome variation profiling by SNP array
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Summary |
Gene expression profiling (GEP) divides DLBCL according to the cell of origin into GCB, ABC and unclassifiable, exhibiting different mutational profiles. The Hans algorithm, a surrogate of GEP, classifies cases expressing CD10, BCL6 and MUM1 as GCB but it is not clear whether all these cases correspond to GCB-type. Accordingly, LBCL with IRF4 rearrangement usually expresses GCB phenotype (CD10+, BCL6+) together with strong MUM1/IRF4.
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Overall design |
The aim of this study was to characterize the molecular heterogeneity of DLBCL triple positive (CD10+ BCL6+MUM1+) in adults. CN alterations were examined in 9 out of 13 cases with available material and IRF4 rearrangement and/or IRF4 mutations using OncoScan platform
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Contributor(s) |
Castrejon-de-Anta N, Frauenfeld L, Balagué O, Quintanilla-Martinez L |
Citation missing |
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Submission date |
Jun 17, 2021 |
Last update date |
Jun 07, 2023 |
Contact name |
Joan Enric Ramiz-Zaldivar |
E-mail(s) |
ramis@clinic.cat
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Phone |
+34 932275400
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Organization name |
IDIBAPS
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Department |
Molecular Pathology Laboratory
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Lab |
Centre Esther Koplowitz (CEK)
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Street address |
Rosselló, 153
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City |
Barcelona |
ZIP/Postal code |
08036 |
Country |
Spain |
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Platforms (1) |
GPL21558 |
[OncoScan_CNV] Affymetrix OncoScan CNV FFPE Assay |
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Samples (9)
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Relations |
BioProject |
PRJNA738923 |