|
| Status |
Public on Jun 20, 2024 |
| Title |
FoxM1-Retinoblastoma Interaction Induces Tumor Microenvironment That Drives Metastasis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A mouse strain expressing an Rb-binding deficient mutant of FoxM1, FoxM1 DD, develops PyMT-driven mammary tumors that are deficient in metastasis. Single-cell RNA-Seq analyses revealed altered tumor microenvironment (TME). Unlike the FoxM1 +/+ tumors, the FoxM1 DD/DD tumors lack tumor-infiltrating cells, resulting from a deficiency in the tumor cell-populations that express factors necessary for their recruitment. Furthermore, FoxM1 DD/DD tumors contain fewer mammary cancer stem/progenitor cells, but more differentiated tumor cells.
|
| |
|
| Overall design |
FoxM1 +/+ PyMT-driven mammary tumors were compared to FoxM1 DD/DD PyMT-driven mammary tumors by single cell RNA-seq (Drop-seq)
|
| |
|
| Contributor(s) |
Zappia MP, Kopanja D, . Frolov MV, Islam AB, Raychaudhuri P |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 21, 2021 |
| Last update date |
Jun 20, 2024 |
| Contact name |
Maria Paula Zappia |
| E-mail(s) |
mpzappia@uic.edu
|
| Organization name |
University of Illinos at Chicago
|
| Department |
Biochemistry and Molecular Genetics
|
| Lab |
Frolov - 2356
|
| Street address |
900 S Ashland Ave
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60607 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (4)
|
|
| Relations |
| BioProject |
PRJNA739718 |
| SRA |
SRP324908 |
Less...
More...