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| Status |
Public on Oct 30, 2009 |
| Title |
Expression profiling of hemocytes from Anopheles gambiae after malaria parasite infection |
| Platform organisms |
Plasmodium falciparum; Anopheles gambiae |
| Sample organism |
Anopheles gambiae |
| Experiment type |
Expression profiling by array
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| Summary |
Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation, and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides. In Anopheles, they contribute to the defense against malaria parasite invasion during the early sporogonic cycle.
We used microarrays to identify if and to what degree circulating hemocytes have altered global expression profiles after infection with the rodent malaria parasite, Plasmodium berghei
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| Overall design |
Hemocytes were isolated 24-28h after infection using the infectious EGFP-CON P. berghei strain (experiment) or an invasion-deficient, Circumsporozoite- and TRAP-related protein (CTRP) knockout strain with the same genetic background as GFP-CON (CTRPko/GFP, control).
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| Contributor(s) |
Pinto SB, Kafatos FC, Michel K |
| Citation(s) |
19940242 |
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| Submission date |
Aug 28, 2009 |
| Last update date |
Jan 24, 2013 |
| Contact name |
Kristin Michel |
| E-mail(s) |
kmichel@ksu.edu
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| Organization name |
Kansas State University
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| Department |
Biology
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| Street address |
267 Chalmers Hall
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| City |
Manhattan |
| State/province |
KS |
| ZIP/Postal code |
66506 |
| Country |
USA |
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| Platforms (1) |
| GPL1321 |
[Plasmodium_Anopheles] Affymetrix Plasmodium/Anopheles Genome Array |
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| Samples (6)
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| GSM446415 |
Hemocytes CTRP-ko-EGFP, biological rep1 |
| GSM446416 |
Hemocytes CTRP-ko-EGFP, biological rep2 |
| GSM446417 |
Hemocytes CTRP-ko-EGFP, biological rep3 |
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| Relations |
| BioProject |
PRJNA120113 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE17866_RAW.tar |
11.5 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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