|
| Status |
Public on Mar 04, 2022 |
| Title |
A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
A missense change in RRAS2 (Gln72-to-Leu), analogous to the Gln61-to-Leu mutation of RAS oncoproteins, has been identified as a hotspot mutation in cancer and Noonan syndrome. However, the relevance of this mutation for in vivo tumorigenesis remains unknown.
Here, we show that R-RAS2(Q72L) is required for optimal tumorigenic activity of human cancer cells.
|
| |
|
| Overall design |
Genome-wide gene expression analyses of control and Rras2(Q72L) knockdown (sh#89) fibrosarcoma cells.
|
| |
|
| Contributor(s) |
Fernández-Pisonero I, Clavaín L, Robles-Valero J, Lorenzo-Martín LF, Caloto R, Nieto B, García-Macías C, Oeste CL, Sánchez-Martín M, Abad A, Hortal A, Caballero D, González M, Vicente-Manzanares M, Dosil M, Alarcón B, Bustelo XR |
| Citation(s) |
35294890 |
| |
| Submission date |
Jul 04, 2021 |
| Last update date |
Jun 03, 2022 |
| Contact name |
L. Francisco Lorenzo-Martín |
| E-mail(s) |
luis.lorenzomartin@epfl.ch
|
| Organization name |
École Polytechnique Fédérale de Lausanne (EPFL)
|
| Lab |
Laboratory of Stem Cell Bioengineering
|
| Street address |
EPFL – SV – IBI – LSCB – Station 15
|
| City |
Lausanne |
| State/province |
Vaud |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA743644 |
Less...
More...