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Series GSE179514 Query DataSets for GSE179514
Status Public on Jun 25, 2024
Title Ago and Fkbp project
Organism Schizosaccharomyces pombe
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary S. pombe nucleophosmin proteins have other functions in addition to the established role in ribosome biogenesis. Indeed, Fkbp39 contributes to silencing of centromeric and subtelomeric heterochromatic transcripts and displays a negative genetic interaction with the RNAi pathway. While the mechanisms of Fkbp39 action on heterochromatin and the negative genetic interaction with RNAi require further investigation, in this study we show that argonaute deletion cells have defects in transcription, shedding light on previously uncharacterized roles of RNAi.
 
Overall design ChIP sequencing, nascent, total RNA and small RNA sequencing in wild type cells and different S. pombe mutants
 
Contributor(s) Ugolini I, Halic M
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Submission date Jul 06, 2021
Last update date Jun 25, 2024
Contact name Mario Halic
E-mail(s) mario.halic@stjude.org
Organization name St. Jude Children’s Research Hospital
Lab Halic
Street address 262 Danny Thomas Place
City Memphis
ZIP/Postal code TN 38105-3678
Country USA
 
Platforms (1)
GPL22681 Illumina HiSeq 1500 (Schizosaccharomyces pombe)
Samples (49)
GSM5419575 S. pombe, wildtype_H3K9me_ChIP1
GSM5419576 S. pombe, fkbp39del_H3K9me_ChIP1
GSM5419577 S. pombe, fkbp39del_ago1del_H3K9me_ChIP1
Relations
BioProject PRJNA744096
SRA SRP327123

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE179514_RAW.tar 2.7 Gb (http)(custom) TAR (of TDF)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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