|
| Status |
Public on Mar 08, 2022 |
| Title |
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers [ATAC melanoma] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
ATAC-seq was used to study the chromatin landscape of CD8 T cells in locally advanced melanoma patients treated with neo-adjuvant/adjuvant Pembrolizumab
|
| |
|
| Overall design |
CD8 naive and Non naive cells were sorted from PBMC and tumor samples from advanced melanoma patients treated with neo-adjuvant/adjuvant Pembrolizumab and chromatin accessibility was assayed for comparison analysis
|
| Web link |
https://doi.org/10.1016/j.immuni.2022.02.004
|
| |
|
| Contributor(s) |
Giles J, Manne S, Wherry EJ |
| Citation(s) |
35263570 |
| Submission date |
Jul 06, 2021 |
| Last update date |
Aug 02, 2022 |
| Contact name |
E JOHN WHERRY |
| Organization name |
University of Pennsylvania
|
| Department |
Systems Pharmacology and Translational Therapeutics,Institute for Immunology
|
| Street address |
421 Curie Blvd,354 BRB II/III
|
| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
|
| Samples (54)
|
|
| This SubSeries is part of SuperSeries: |
| GSE179613 |
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers |
|
| Relations |
| BioProject |
PRJNA744258 |
| SRA |
SRP327217 |
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