|
| Status |
Public on Dec 21, 2021 |
| Title |
Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties II |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
This study reveals supeior efficiacy of triple combination treatment (TCT) based on anti-PD-(L)1 and anti-4-1BB/OX40 and describes immunological mechanisms underlying synergism between the treatment components
|
| |
|
| Overall design |
Using scRNA-Seq of TILs isolated from isotype-treated mice we defined a functional and phenotypic T cell heterogeneity within non treated tumors.
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| |
|
| Contributor(s) |
Yang W, Budimir N |
| Citation(s) |
34903555 |
| |
| Submission date |
Jul 29, 2021 |
| Last update date |
Dec 22, 2021 |
| Contact name |
Wenjing Yanf |
| E-mail(s) |
wenjing.yang3@pfizer.com
|
| Organization name |
Pfizer
|
| Department |
Oncology
|
| Street address |
10770 Science Center Drive
|
| City |
San Diego |
| State/province |
CA |
| ZIP/Postal code |
92121 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (1) |
|
| This SubSeries is part of SuperSeries: |
| GSE181152 |
Combinatorial Immunotherapy Induces Tumor Infiltrating CD8+ T Cells with Distinct Functional, Migratory, and Stem-Like Properties |
|
| Relations |
| BioProject |
PRJNA750798 |
| SRA |
SRP330494 |
