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| Status |
Public on Aug 02, 2021 |
| Title |
Functional multi-omics reveals genetic and pharmacologic regulation of surface CD38 in multiple myeloma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goals of this study are to use multi-omics to design strategies to enhance efficacy of CD38-targeting immunotherapies in myeloma. We compared RNA-seq to cell surface proteomics after genetic and chemical manipulation of CD38 levels in myeloma cell lines.
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| Overall design |
Examination of cell surface proteins, phosphoproteins, and RNA levels in myeloma cell lines with different levels of CD38 expression
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| Contributor(s) |
Choudhry P, Gugliemini O, Geng H, Sarin V, Sarah L, Lin YT, Ramkumar P, Paranjape N, Marcoulis M, Wang D, Phojanokong P, Steri V, Hann B, Kampmann M, Wiita AP |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Aug 01, 2021 |
| Last update date |
Aug 02, 2021 |
| Contact name |
Arun P Wiita |
| Organization name |
University of California San Francisco
|
| Street address |
185 Berry St, Ste 290/Rm 2410
|
| City |
San Francisco |
| State/province |
CALIFORNIA |
| ZIP/Postal code |
94107 |
| Country |
USA |
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| Platforms (1) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA751385 |
| SRA |
SRP330771 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE181277_AMO_scri-VS-AMO_CD38i.DEseq2_Method.GeneDiffExp.xls.gz |
3.4 Mb |
(ftp)(http) |
XLS |
| GSE181277_DMSO-VS-Treated.DEseq2_Method.GeneDiffExp.xls.gz |
3.9 Mb |
(ftp)(http) |
XLS |
| GSE181277_FilterSummary.xls.gz |
537 b |
(ftp)(http) |
XLS |
| GSE181277_K12_scri-VS-K12_CD38i.DEseq2_Method.GeneDiffExp.xls.gz |
3.4 Mb |
(ftp)(http) |
XLS |
| GSE181277_RPMI8266_GSE181277_DMSO4ATRA-VS-RPMI8266_ATRA.DEseq2_Method.GeneDiffExp.xls.gz |
3.2 Mb |
(ftp)(http) |
XLS |
| GSE181277_RPMI8266_GSE181277_DMSO4ATRA-VS-RPMI8266_DMSO4Aza.DEseq2_Method.GeneDiffExp.xls.gz |
3.3 Mb |
(ftp)(http) |
XLS |
| GSE181277_RPMI8266_GSE181277_DMSO4ATRA-VS-RPMI8266_Pano.DEseq2_Method.GeneDiffExp.xls.gz |
3.5 Mb |
(ftp)(http) |
XLS |
| GSE181277_RPMI8266_GSE181277_DMSO4Aza-VS-RPMI8266_Aza.DEseq2_Method.GeneDiffExp.xls.gz |
3.5 Mb |
(ftp)(http) |
XLS |
| GSE181277_RPMI8266_scri-VS-RPMI8266_CD38i.DEseq2_Method.GeneDiffExp.xls.gz |
3.4 Mb |
(ftp)(http) |
XLS |
| GSE181277_Scri-VS-CD38i.DEseq2_Method.GeneDiffExp.xls.gz |
3.7 Mb |
(ftp)(http) |
XLS |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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