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| Status |
Public on Oct 15, 2009 |
| Title |
Punctual ablation of Foxp3+ T cells unleashes an autoimmune lesion |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
How do Treg cells control an autoimmune lesion? We depleted Foxp3+ Treg cells in autoimmune prone TCR transgenic BDC2.5 mice on the NOD background
Kinetic of gene-expression changes in CD4 T cells isolated for pancreas and pancreas draining lymph node (PLN) of Foxp3-DTR.BDC2.5/NOD mice after Treg cell ablation
Keywords: T cell activation/ differentiation after Treg depletion timecourse
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| Overall design |
CD4 T cells were isolated from pancreas and PLN at 0, 15 and 24 hours after diphtheria toxin application into 4-6 week old female Foxp3-DTR.BDC2.5/NOD transgenic mice
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| Contributor(s) |
Feuerer M, Benoist C, Mathis D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Sep 16, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
CBDM Lab |
| E-mail(s) |
cbdm@hms.harvard.edu
|
| Phone |
617-432-7747
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| Organization name |
Harvard Medical School
|
| Department |
Microbiology and Immunobiology
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| Lab |
CBDM
|
| Street address |
77 Avenue Louis Pasteur
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| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA119423 |
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