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| Status |
Public on Oct 21, 2021 |
| Title |
CALR frameshift mutations accelerate maturation of megakaryocytes in MPN patient-derived iPS cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this dataset, we compare the gene expression data of induced pluripotent stem (iPS) cell-derived CD61+ megakaryocytes carrying heterozygous or homozygous Calreticulin (CALR) ins5 mutations or the CALR wildtype gene.
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| Overall design |
9 samples; Three biological replicates were analyzed per genotype. Het - heterozygous CALRins5 mutation; Hom - homozygous CALR mutation; WTcr - CALR wildtype generated by CRISPR/Cas9 using the respective mutated clone.
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| Contributor(s) |
Olschok K, Han L, de Toledo MA, Böhnke J, Graßhoff M, Costa IG, Theocharides A, Maurer A, Schüler HM, Buhl EM, Pannen K, Baumeister J, Kalmer M, Gupta S, Boor P, Gezer D, Brümmendorf TH, Zenke M, Chatain N, Koschmieder S |
| Citation(s) |
34678208 |
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| Submission date |
Aug 19, 2021 |
| Last update date |
Nov 30, 2021 |
| Contact name |
Steffen Koschmieder |
| E-mail(s) |
skoschmieder@ukaachen.de
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| Organization name |
RWTH Aachen
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| Department |
Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation
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| Street address |
Pauwelsstraße 30
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| City |
Aachen |
| State/province |
Nordrhein-Westfalen |
| ZIP/Postal code |
52074 |
| Country |
Germany |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA756365 |
| SRA |
SRP333390 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE182479_gene_counts_fixed_calr_untreated.csv.gz |
962.6 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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