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Series GSE183339 Query DataSets for GSE183339
Status Public on Sep 08, 2021
Title RNA sequencing of lung tissue from Angiotensin2/TRV023/losartan treated MCT rats
Organism Rattus norvegicus
Experiment type Expression profiling by high throughput sequencing
Summary We report the application of RNA sequencing in lung tissues of MCT rats, that were treated with Angiotensin 2 or TRV023 or Losartan to study their effects on Pulmonary hypertension. We received FPKM data of each gene from each group of MCT rats. The gene expression of the study MCT rats were normalized to control MCT rat. The differentially expressed genes in Angiotensin 2 and TRV023 treated MCT rats, confirmed that like Angiotensin 2, TRV023 is also involved in vascular remodelling and lead to worsening of pulmonary hypertension.
 
Overall design MCT rats treated with Angiotensin 2 or TRV023 or Losartan
 
Contributor(s) Viswanathan G, Ma Z, Rajagopal S
Citation(s) 34869949
Submission date Sep 03, 2021
Last update date Nov 08, 2023
Contact name Gayathri Viswanathan
E-mail(s) gayu2605v@gmail.com
Phone 9199370010
Organization name Duke University
Department Cardiology
Lab Sudarshan Rajagopal
Street address 0150, Carl building, 130 Research Drive
City Durham
State/province NC
ZIP/Postal code 27710
Country USA
 
Platforms (1)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
Samples (12)
GSM5555810 MCT rats- PBS [Veh_923]
GSM5555811 MCT rats- PBS [Veh_924]
GSM5555812 MCT rats- PBS [Veh_963]
Relations
BioProject PRJNA760313
SRA SRP335509

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE183339_Ang2vsVehicle_DEG.txt.gz 2.4 Mb (ftp)(http) TXT
GSE183339_Ang2vsVehicle_DEG_all.txt.gz 31.6 Kb (ftp)(http) TXT
GSE183339_Ang2vsVehicle_DEG_down.txt.gz 7.6 Kb (ftp)(http) TXT
GSE183339_Ang2vsVehicle_DEG_up.txt.gz 24.6 Kb (ftp)(http) TXT
GSE183339_FPKM_values_for_hits.xlsx 8.9 Kb (ftp)(http) XLSX
GSE183339_LosartanvsVehicle_DEG.txt.gz 2.5 Mb (ftp)(http) TXT
GSE183339_LosartanvsVehicle_DEG_all.txt.gz 784 b (ftp)(http) TXT
GSE183339_LosartanvsVehicle_DEG_down.txt.gz 220 b (ftp)(http) TXT
GSE183339_LosartanvsVehicle_DEG_up.txt.gz 783 b (ftp)(http) TXT
GSE183339_Matrix_table.xlsx 3.1 Mb (ftp)(http) XLSX
GSE183339_Trv023vsVehicle_DEG.txt.gz 2.5 Mb (ftp)(http) TXT
GSE183339_Trv023vsVehicle_DEG_all.txt.gz 15.3 Kb (ftp)(http) TXT
GSE183339_Trv023vsVehicle_DEG_down.txt.gz 9.5 Kb (ftp)(http) TXT
GSE183339_Trv023vsVehicle_DEG_up.txt.gz 6.2 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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