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| Status |
Public on Nov 10, 2021 |
| Title |
ATAC-Seq based chromatin accessibilty profile of human monocytes treated with MV130 or its excipient |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
MV130 is an inactivated polybacterial mucosal vaccine that confers protection to patients against recurrent respiratory infections, including those of viral etiology. We showed that MV130 induces long term heterologous protection against viral respiratory infections in mice by a mechanism associated with the induction of trained immunity. Moreover, we found that MV130 induces reprogramming of in vitro human monocytes promoting metabolic changes and enhanced cytokine production. To assess the role of epigenetic changes in MV130-mediated trained immunity induction in human monocytes we measured the chromatin accessibility landscape using ATAC-seq.
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| Overall design |
Three replicate samples of human monocytes were exposed to MV130 or its excipient to identify changes in the chromatin accesibility profile using ATAC-seq.
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| Contributor(s) |
Brandi P, Sancho D |
| Citation(s) |
34986349 |
| Submission date |
Sep 05, 2021 |
| Last update date |
Jan 28, 2022 |
| Contact name |
Manuel J Gomez |
| E-mail(s) |
mjgomezr@cnic.es
|
| Organization name |
CNIC
|
| Lab |
Bioinformatics Unit
|
| Street address |
Melchor Fernández Almagro, 3
|
| City |
Madrid |
| State/province |
Madrid |
| ZIP/Postal code |
28029 |
| Country |
Spain |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE183721 |
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections |
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| Relations |
| BioProject |
PRJNA760957 |
| SRA |
SRP335770 |
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