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Series GSE184189 Query DataSets for GSE184189
Status Public on Nov 09, 2021
Title Transcriptional profiling to elucidate processes regulated by 2',3'-cyclic nucleotide phosphodiesterase (CNPase) in Salmonella Typhimurium 14028s (Salmonella) I.
Organism Salmonella enterica subsp. enterica serovar Typhimurium
Experiment type Expression profiling by high throughput sequencing
Summary The impact of Ribonuclease I (RNase I) on global gene expression in Salmonella was investigated by deletion of the 'rna' gene which encodes RNase I. RNase I is capable of hydrolyzing RNA into 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) such that deletion of 'rna' drastically reduces 2',3'-cNMPs presence to undetectable levels. This 'rna' deletion mutant was compared to Salmonella 14028s WT strain.
Overall design Global transcript levels in a 'rna' deletion strain of Salmonella were compared to levels in 14028s WT control cells in order to identify cellular processes modulated by RNase I.
Contributor(s) Fontaine BM, Kurasz JE, Duggal Y, Chauhan SS, Marotta N, Karls AC, Weinert EE
Citation(s) 34662237
Submission date Sep 15, 2021
Last update date Feb 08, 2022
Contact name Emily Weinert
Organization name Pennsylvania State University
Department Biochemistry and Molecular Biology
Street address 306 Althouse Laboratory
City University Park
State/province PA
ZIP/Postal code 16802
Country USA
Platforms (1)
GPL30637 NextSeq 2000 (Salmonella enterica subsp. enterica serovar Typhimurium)
Samples (6)
GSM5580022 drna1
GSM5580023 drna2
GSM5580024 drna3
BioProject PRJNA763525
SRA SRP337232

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Supplementary file Size Download File type/resource
GSE184189_All_Quantified_Genes_Salty_drna_v_WT.tsv.gz 329.6 Kb (ftp)(http) TSV
GSE184189_hisat2_counts_drna_WT_v_drna.txt.gz 73.4 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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