 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Sep 16, 2022 |
| Title |
Cardiopulmonary Phenotyping of Sex-Based Differences in a Feline Model of HFpEF |
| Organism |
Felis catus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
In order to better understand sex-related differences of heart failure with preserved ejection fraction (HFpEF), male and female kittens underwent aortic contriction surgery (banding) or sham surgery (normal). Slow progressive pressure overload was then compared between male and female kittens, analyzing structural and functional phenotypes. Transcriptional differences between male and female kittens were investigated via single nuclear RNA sequencing (snRNA-seq) within left ventricle tissue.
|
| |
|
| Overall design |
Compared transcriptional differences in left ventricles between male and female kittens when placed under aortic constriction (banding)
|
| |
|
| Contributor(s) |
Eaton DM, Berretta RM, Lynch JE, Travers JG, Woulfe KC, Pfeiffer RD, Hulke ML, Lau E, Zhao H, Hobby AR, Schena G, Johnson JP, Wallner M, Lam PY, Tucker NR, McKinsey TA, Wolfson MR, Houser SR |
| Citation(s) |
36053749 |
| Submission date |
Sep 17, 2021 |
| Last update date |
Oct 31, 2022 |
| Contact name |
Nathan Tucker |
| E-mail(s) |
ntucker@mmri.edu
|
| Organization name |
Masonic Medical Research Institute
|
| Street address |
2150 Bleecker St
|
| City |
Utica |
| State/province |
NY |
| ZIP/Postal code |
13501 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL28702 |
Illumina NovaSeq 6000 (Felis catus) |
|
| Samples (15)
|
|
| Relations |
| BioProject |
PRJNA764081 |
| SRA |
SRP337594 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE184328_feline_adata_full_processed.h5ad.gz |
357.9 Mb |
(ftp)(http) |
H5AD |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...