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Series GSE18458 Query DataSets for GSE18458
Status Public on Jul 07, 2010
Title Genome wide DNA Methylation Study in Cornelia de Lange Syndrome
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary Differential DNA methylation was identified in CdLS, and correlates to cohesin binding as well. However, DNA methylation may only be one of several events that regulate gene expression in humans.
 
Overall design 63 Lymphoblastoid cell lines (LCLs) from 39 CdLS probands, 2 RBS probands and 22 gender and racial matched healthy controls were tested on HumanMethylation27 DNA Analysis BeadChip (Illumina) which carries 27,578 highly informative CpG sites derived from the well-annotated NCBI CCDS database
 
Contributor(s) Liu J, Zhang Z, Bando M, Itoh T, Deardorff MA, Li JR, Clark D, Kaur M, Tatsuro K, Kline AD, Vega H, Chang C, Jackson LG, Spinner NB, Shirahige K, Krantz ID
Citation(s) 20448023
Submission date Oct 07, 2009
Last update date Jan 02, 2015
Contact name IAN D. KRANTZ
E-mail(s) ian2@mail.med.upenn.edu
Phone 215-590-2828
Organization name The Children's Hospital of Philadelphia
Department Division of Human and Molecular Genetics
Lab 1012G, ARC
Street address 34th and Civic Blvd.
City Philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (72)
GSM459763 SMC1A mutant CdLS proband: CDL-017-98-P
GSM459764 severly affected NIPBL mutant CdLS proband: CDL-095-00P
GSM459765 severly affected NIPBL mutant CdLS proband: CDL-006-98-P
Relations
BioProject PRJNA118177

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18458_RAW.tar 5.8 Mb (http)(custom) TAR
GSE18458_raw_intensities.txt.gz 17.3 Mb (ftp)(http) TXT
Processed data included within Sample table
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