NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE184712 Query DataSets for GSE184712
Status Public on Sep 27, 2021
Title Melatonin Enhances Osteoblastogenesis from Senescent Mesenchymal Stem Cells via NSD2 Mediated Chromatin Remodeling [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during cell fate decisions, but the underlying mechanisms are not fully understood. Here we demonstrate that RUNX2 and BGLAP osteogenic genes coordinate histone H3 lysine 36 dimethylation (H3K36me2) and transcriptional elongation factor Pol II to regulate chromatin dynamic and gene transcription during osteogenesis. Mechanistically, melatonin favored osteogenic differentiation via the NSD2-mediated modification of H3K36me2 on the promoters of osteogenic driver genes in MSCs from the old donors.
 
Overall design Examination MSCs from the old donors treated with melatonin and MSCs from different age groups
 
Contributor(s) Xie Y, Han N, Li F, Wang L
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Sep 23, 2021
Last update date Sep 27, 2021
Contact name Liu Zhiqiang
E-mail(s) zhiqiangliu@tmu.edu.cn
Organization name Tianjin Medical University
Street address 22 Qxiangtai Rd
City Tianjin
ZIP/Postal code 300070
Country China
 
Platforms (1)
GPL23479 BGISEQ-500 (Mus musculus)
Samples (12)
GSM5596046 O1_Mel
GSM5596047 O1_Veh
GSM5596048 O3_Mel
This SubSeries is part of SuperSeries:
GSE184714 Melatonin Enhances Osteoblastogenesis from Senescent Mesenchymal Stem Cells via NSD2 Mediated Chromatin Remodeling.
Relations
BioProject PRJNA765793
SRA SRP338516

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184712_RNAseq_mBMSC_Differentially_Expressed_Genes.xlsx 5.2 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.