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Series GSE184900 Query DataSets for GSE184900
Status Public on Apr 25, 2022
Title Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
Organism Homo sapiens
Experiment type Methylation profiling by genome tiling array
Third-party reanalysis
Summary Myxopapillary ependymoma is a heterogeneous disease with respect to histopathology and clinical outcome. However, there are no diagnostic markers or clinical parameters that reliably predict the progression-free survival of the respective patients. We analyzed 185 tumors that classified as myxopapillary ependymoma based on global DNA methylation. Of these, 46 samples have been previously analyzed in GSE65362, GSE90496 or GSE109381. Using k-means clustering, our series split up into two distinct subtypes: MPE-A occurred in younger patients (median age 27 years) and were significantly enriched with tumors demonstrating papillary morphology and MGMT promoter methylation. Half of these tumors could not be totally resected, and 85% relapsed within 10 years. On the other hand, MPE-B occurred at a median age of 45 years. They included a significantly higher number of tumors with an initial diagnosis of WHO grade II and tanycytic morphology. Importantly, patients within this subgroup had a significantly better outcome with a relapse rate of only 33% in 10 years.
 
Overall design 185 specimens were analyzed using the Illumina Infinium HumanMethylation450 or the MethylationEPIC BeadChip.
 
Contributor(s) Bockmayr M, Schüller U
Citation(s) 35380708
Submission date Sep 28, 2021
Last update date Sep 23, 2024
Contact name Michael Bockmayr
E-mail(s) m.bockmayr@uke.de
Organization name University Medical Center Hamburg-Eppendorf
Department Pediatric Hematology and Oncology
Street address Martinistr. 52
City Hamburg
ZIP/Postal code 20251
Country Germany
 
Platforms (2)
GPL13534 Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
GPL21145 Infinium MethylationEPIC
Samples (139)
GSM5599984 Genomic DNA from myxopapillary ependymoma 1
GSM5599985 Genomic DNA from myxopapillary ependymoma 2
GSM5599986 Genomic DNA from myxopapillary ependymoma 3
Relations
Reanalysis of GSM2404735
Reanalysis of GSM1593568
Reanalysis of GSM1593575
Reanalysis of GSM1593583
Reanalysis of GSM1593572
Reanalysis of GSM1593565
Reanalysis of GSM1593564
Reanalysis of GSM1593570
Reanalysis of GSM2405181
Reanalysis of GSM2405068
Reanalysis of GSM1593567
Reanalysis of GSM1593576
Reanalysis of GSM1593577
Reanalysis of GSM2405158
Reanalysis of GSM2404713
Reanalysis of GSM1593573
Reanalysis of GSM1593562
Reanalysis of GSM1593566
Reanalysis of GSM1593582
Reanalysis of GSM2404533
Reanalysis of GSM1593561
Reanalysis of GSM1593579
Reanalysis of GSM2940935
Reanalysis of GSM2940944
Reanalysis of GSM2941142
Reanalysis of GSM2941141
Reanalysis of GSM2941145
Reanalysis of GSM2941230
Reanalysis of GSM2941378
Reanalysis of GSM2941403
Reanalysis of GSM2941438
Reanalysis of GSM2941643
Reanalysis of GSM2941678
Reanalysis of GSM2941684
Reanalysis of GSM2940784
Reanalysis of GSM2940923
Reanalysis of GSM1593586
Reanalysis of GSM1593563
Reanalysis of GSM1593569
Reanalysis of GSM1593574
Reanalysis of GSM2941021
Reanalysis of GSM1593571
Reanalysis of GSM1593581
Reanalysis of GSM1593580
Reanalysis of GSM1593584
Reanalysis of GSM1593585
BioProject PRJNA767016

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184900_RAW.tar 2.0 Gb (http)(custom) TAR (of IDAT)
GSE184900_processed_data.txt.gz 483.3 Mb (ftp)(http) TXT
Processed data are available on Series record

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