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Series GSE184986 Query DataSets for GSE184986
Status Public on Jan 26, 2023
Title Inhibition of Fap Promotes Cardiac Repair by Stabilizing BNP
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Inhibition of fibroblast activation protein promotes cardiac repair by stabilizing brain natriuretic peptide after myocardial infarction
 
Overall design Bulk RNA-seq data of mouse cardiac fibroblasts (CFs) cultured alone in 3D GelMA hydrogel vs mouse CFs co-cultured with cardiac and lung endothelial cells in a ratio of 2:1 in 3D GelMA hydrogel.
RNA-seq libraries from 3 biological replicates of mouse CFs cultured alone in 3D GelMA hydrogel vs mouse CFs co-cultured with cardiac and lung endothelial cells in a ratio of 2:1 in 3D GelMA hydrogel. Samples were subjected to paired-end sequencing by HiSeq XTen systems (Illumina, 150 bp reads).

This study aims to test whether Fap is a critical regulator of cardiac repair after MI, and to uncover the underlying cellular and molecular mechanisms for better treatment of Myocardial infarction (MI).
We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different tissues from sham, MI, FAPI (MI), FapKO (MI).
Comparative gene expression profiling analysis of RNA-seq data for border zones of sham, MI, FAPI (MI), FapKO (MI).
Web link https://pubmed.ncbi.nlm.nih.gov/36756875/
 
Contributor(s) Yue R, Xu D, Zhang L, Sun Y, Ma M
Citation(s) 36756875
Submission date Sep 29, 2021
Last update date Apr 27, 2023
Contact name Dandan Cao
E-mail(s) 1931465@tongji.edu.cn
Phone 17853136996
Organization name Tongji University
Street address 1239 Siping Road, Yangpu District
City Shanghai
ZIP/Postal code 200092
Country China
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (21)
GSM5602738 co-culture-rep1
GSM5602739 co-culture-rep2
GSM5602740 co-culture-rep3
Relations
BioProject PRJNA767326
SRA SRP339285

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE184986_RAW.tar 4.3 Mb (http)(custom) TAR (of TXT)
GSE184986_syx_rawcounts.csv.gz 399.5 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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