NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE186542 Query DataSets for GSE186542
Status Public on Feb 09, 2023
Title Nucleus pulposus related lncRNA and mRNA expression profiles in intervertebral disc degeneration
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Intervertebral disc degeneration (IDD) leads to low back pain and disability globally. The pathophysiology of IDD is not entirely understood. There is increasing evidence that long noncoding RNAs (lncRNAs) play a key regulatory role in a wide range of biological processes. The purpose of this study was to comprehensively lncRNA and mRNA expression profiles of human intervertebral disc (IVD) tissues, specifically nucleus pulpous (NP) tissues, with early and advanced stages of disc degeneration. The overview of lncRNA and mRNA expression profiles in the current study revealed that differentially expressed lncRNAs and mRNAs were identified that have been reported to be relevant to IDD. Importantly, differentially expressed lncRNAs and mRNAs that regulate the major signaling pathways, such as NF-κB, MAPK, and Wnt signaling, that are well known to be responsible for the pathogenesis of IDD.
 
Overall design Human NP tissues obtained from spine surgeries were used in this study. The samples were divided into two groups: early stage degeneration (n=3, Pfirrmann’s MRI grade: I-III) and advanced stage degeneration (n=3, grade: IV-V). we conducted lncRNA and mRNA profiling in 3 human control nucleus pulposus tissue and 3 degenerative nucleus pulposus tissue by RNA sequencing (RNA-seq).
 
Contributor(s) Wu Y, Liu H, Li S
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Oct 25, 2021
Last update date Feb 09, 2023
Contact name Yanjiao Wu
E-mail(s) colt2046@126.com
Phone 18512376504
Organization name Southern Medical University
Street address street address: No.1023,South Shatai Road, Baiyun District
City Guangzhou
State/province Guangdong
ZIP/Postal code 510515
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM5655437 NP_control_1
GSM5655438 NP_control_2
GSM5655439 NP_control_3
Relations
BioProject PRJNA774342
SRA SRP343047

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE186542_gene_expression.txt.gz 2.2 Mb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.