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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Mar 01, 2023 |
| Title |
Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid [intestinal organoids] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We evaluated the effects of arachidonic acid (AA) on intestinal stem cell regeneration by RNA-seq and found that AA treatment led to strong upregulation of genes that are associated with stem cell reprogramming across the time points. AA elicits a conserved stem cell regeneration program in mouse intestinal organoids.
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| Overall design |
mRNA profiles of mouse intestinal organoids during time course of treatment with vehicle, arachidonic acid or 6,16-dimethyl PGE2.
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| Contributor(s) |
Eskiocak O, Meydan C, Alici-Garipcan A, Shah V, Meyer H, Beyaz S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Nov 04, 2021 |
| Last update date |
Mar 01, 2023 |
| Contact name |
Aybuke Alici |
| E-mail(s) |
garipca@cshl.edu
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| Organization name |
Cold Spring Harbor Laboratory
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| Street address |
1 Bungtown Rd.
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| City |
Cold Spring Harbor |
| State/province |
NY |
| ZIP/Postal code |
11724 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (26)
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| GSM5672441 |
intestinal organoids, AA_D1#1 |
| GSM5672442 |
intestinal organoids, AA_D1#2 |
| GSM5672443 |
intestinal organoids, AA_D1#3 |
| GSM5672444 |
intestinal organoids, PGE2_D1#1 |
| GSM5672445 |
intestinal organoids, PGE2_D1#2 |
| GSM5672446 |
intestinal organoids, PGE2_D1#3 |
| GSM5672447 |
intestinal organoids, Veh_D3#1 |
| GSM5672448 |
intestinal organoids, Veh_D3#2 |
| GSM5672449 |
intestinal organoids, Veh_D3#3 |
| GSM5672450 |
intestinal organoids, AA_D3#1 |
| GSM5672451 |
intestinal organoids, AA_D3#2 |
| GSM5672452 |
intestinal organoids, AA_D3#3 |
| GSM5672453 |
intestinal organoids, PGE2_D3#1 |
| GSM5672454 |
intestinal organoids, PGE2_D3#2 |
| GSM5672455 |
intestinal organoids, PGE2_D3#3 |
| GSM5672456 |
intestinal organoids, Veh_D6#1 |
| GSM5672457 |
intestinal organoids, Veh_D6#2 |
| GSM5672458 |
intestinal organoids, Veh_D6#3 |
| GSM5672459 |
intestinal organoids, Veh_D6#4 |
| GSM5672460 |
intestinal organoids, AA_D6#1 |
| GSM5672461 |
intestinal organoids, AA_D6#2 |
| GSM5672462 |
intestinal organoids, AA_D6#3 |
| GSM5672463 |
intestinal organoids, AA_D6#4 |
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| This SubSeries is part of SuperSeries: |
| GSE210730 |
Epigenetic reprogramming of intestinal stemness by dietary arachidonic acid |
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| Relations |
| BioProject |
PRJNA777928 |
| SRA |
SRP344605 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE188213_all.tsv.gz |
850.7 Kb |
(ftp)(http) |
TSV |
| GSE188213_all_d6.tsv.gz |
539.1 Kb |
(ftp)(http) |
TSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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