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| Status |
Public on Mar 22, 2023 |
| Title |
Isoginkgetin induces autophagic cell death in hepatocellular carcinoma [ChIP-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Purpose: Our previous studies have identified isoginkgetin as an inducer of autophagic cell death in hepatocellular carcinoma. We set out to analyze how isoginkgetin regulates the genome-wide enhancer activity in HepG2 cells.
Methods: ChIP-seq for H3K27ac was performed in HepG2 followed by treatment with 20 μM isoginkgetin for 24 h.
Conclusions: Isoginkgetin treatment reduces the expression of glucose transporters and inhibts SLC2A1 enhancer activity in HepG2 cells.
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| Overall design |
ChIP-seq was performed with two repetitions in HepG2 cells followed by treatment with20 μM Isoginkgetin for 24 h. The genome-wide enhancer activity was studied by H3K27ac ChIP sequencing.
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| Contributor(s) |
Yao J, Shi C, Zeng X |
| Citation(s) |
36048765 |
| |
| Submission date |
Nov 10, 2021 |
| Last update date |
Mar 23, 2023 |
| Contact name |
Jie Yao |
| E-mail(s) |
yaojie@whu.edu.cn
|
| Phone |
18771075190
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| Organization name |
wuhan university
|
| Street address |
wuhan hubei province
|
| City |
wuhan |
| State/province |
湖北 |
| ZIP/Postal code |
430072 |
| Country |
China |
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| Platforms (1) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE188535 |
Isoginkgetin induces autophagic cell death in hepatocellular carcinoma |
|
| Relations |
| BioProject |
PRJNA779372 |
| SRA |
SRP345406 |
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