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| Status |
Public on Nov 10, 2022 |
| Title |
Microarray profiling analysis of microRNAs expression in diabetes samples |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
Expression profiling by RT-PCR
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| Summary |
At present, there is no effective treatment for diabetic wounds, and the cost of treatment is high. MicroRNAs (miRNAs) plays an important role in the process of diabetic wound healing. By regulating the expression of target genes, it regulates growth factors, cytokines and signal pathways, thereby affecting various stages of ulcer healing such as hemostasis, anti-inflammatory, proliferation and remodeling. In this study, differential expression of miRNAs in diabetic wound was screened. MiR-206 was selected as the research object to detect the effect of miR-206 on the proliferation of fibroblasts and vascular endothelial cell by regulating HIF-1?. Finally, in vivo studies showed that miR-206 antagomir could promote the expression of HIF-1?, CD34 and VEGF, and further promote wound healing in diabetic rats.
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| Overall design |
Three normal skin samples and three diabetes samples were collected in the present study.
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| Contributor(s) |
Yang W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 14, 2021 |
| Last update date |
Nov 10, 2022 |
| Contact name |
KAI TAO |
| E-mail(s) |
luzongzhengxing@sina.com
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| Phone |
+862428851316
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| Organization name |
Reconstructive and Plastic Surgery, The General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District
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| Street address |
Reconstructive and Plastic Surgery, The General Hospital of Northern Theater Command, No. 83, Wenhua Road, Shenhe District
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| City |
SHENYANG |
| State/province |
State |
| ZIP/Postal code |
110016 |
| Country |
China |
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| Platforms (1) |
| GPL30951 |
Genecopoeia miProfile Custom miRNA qPCR Arrays |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA780905 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE188783_fold-change.txt.gz |
1.6 Kb |
(ftp)(http) |
TXT |
| GSE188783_non-normalized.txt.gz |
3.6 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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