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| Status |
Public on Mar 02, 2022 |
| Title |
Transcriptomic profiles of jejunum, liver, spleen and jejunal Peyer's patches in piglets exposed to Fumonisin B1 |
| Organism |
Sus scrofa |
| Experiment type |
Expression profiling by array
Third-party reanalysis
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| Summary |
Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium species. In mammals, this toxin causes multiple organ-specific damages. Among its multiple effects, FB1 promotes hepatotoxicity, is immunotoxic and alters the intestinal functions. Despite its inhibitory effect on de novo ceramide synthesis, the molecular mechanism of FB1 action and toxicity remain unclears. In order to explore the mechanism of FB1 toxicity in multiple tissues, we analyzed the transcriptome of the jejunal section, liver, spleen and jejunal Peyer's patches which are targeted by FB1.
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| Overall design |
Ten weeks old pigs were sacrificed after 4 weeks feeding with control diet (6 pigs) or feeding with control diet artificially contaminated with 10 ppm Fumonisin B1 (6 pigs). After sacrifice Jejunal section, liver, spleen and jejunal Peyer's patches samples from each of 12 pigs are collected and used for microarray gene expression study.
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| Contributor(s) |
Loiseau N, Gourbeyre P, Laffitte J, Fayet J, Cossalter A, Lippi Y, Pinton P, Oswald I |
| Citation(s) |
35202111 |
| Submission date |
Nov 19, 2021 |
| Last update date |
Mar 03, 2022 |
| Contact name |
Yannick Lippi |
| E-mail(s) |
yannick.lippi@inrae.fr
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| Organization name |
INRAE
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| Department |
GeT-TRiX facility
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| Lab |
TOXALIM UMR1331
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| Street address |
180 chemin de tournefeuille
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| City |
Toulouse |
| ZIP/Postal code |
31300 |
| Country |
France |
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| Platforms (1) |
| GPL19893 |
Agilent-037880/INRA Sus scrofa 60K v1 (enriched with immune system muscle and adipose tissue genes) [Probe names] |
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| Samples (47)
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| Relations |
| BioProject |
PRJNA781945 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE189198_RAW.tar |
495.0 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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