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Series GSE189348 Query DataSets for GSE189348
Status Public on Jan 12, 2024
Title Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_forebrain]
Organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. We first investigated the effects of sleep deprivation on the brain miRNA transcriptome. Sleep deprivation affected 52 miRNAs in the whole brain, and particularly miR-709, an activity-dependent microRNA, enriched in the cerebral cortex.
 
Overall design Sixteen C57BL/6J male mice (12 weeks old) were used, divided in the sleep-drepived group (n=8) and the non-treated control group (n=8). After removal of an outlier miRNA sample, data from 7 sleep-deprived and 8 control mice were retained in the data set for statistical analysis.
 
Contributor(s) Kompotis K, Mang G, Franken P, Wigger L
Citation(s) 38207077
Submission date Nov 22, 2021
Last update date Jan 13, 2024
Contact name Leonore Wigger
E-mail(s) leonore.wigger@sib.swiss
Organization name Swiss Institute of Bioinformatics
Lab Vital-IT
Street address AmphipĂ´le Building
City Lausanne
ZIP/Postal code 1015
Country Switzerland
 
Platforms (1)
GPL30990 Agilent-021828 Mouse miRNA Microarray (miRNA_ID version)
Samples (15)
GSM5699660 forebrain_ctl01_rep1
GSM5699661 forebrain_ctl03_rep2
GSM5699662 forebrain_ctl07_rep3
This SubSeries is part of SuperSeries:
GSE189353 Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner
Relations
BioProject PRJNA782634

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189348_Matrix_updated_names.txt.gz 21.5 Kb (ftp)(http) TXT
GSE189348_RAW.tar 12.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table
Processed data are available on Series record

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