|
| Status |
Public on Nov 21, 2023 |
| Title |
Self-assembled hyaluronic acid nanomedicine as a topical therapeutic agent for targeted modulation of dysregulated skin barrier and immune responses in a mouse model of psoriasis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: profiling the differential transcripts usage in HACN treated macrophage polarization toward proinflammatory M1 polarization
Methods: transcriptome analysis by the RNA-seq via mRNA pull-down
Results: The mRNA profiles by RNA sequencing in bone marrow-derived macrophages showed that the whole gene expression patterns altered by lipopolysaccharide (LPS) were restored by HACN pre-treatment, and most of those genes were related to the inflammatory response including M1 polarization
Conclusions: The inhibitory effects of HA-NPs on LPS-induced M1 polarization are attributed to the presence of self-assembled HA shell, not the hydrophobic constituents and the free HAs.
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| |
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| Overall design |
N: control group, P: LPS treaed group, X LPS+HACA treated group
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| |
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| Contributor(s) |
Kim W, Kim J |
| Citation missing |
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| |
| Submission date |
Nov 22, 2021 |
| Last update date |
Nov 21, 2023 |
| Contact name |
Jung-Woong Kim |
| E-mail(s) |
jungkim@cau.ac.kr
|
| Organization name |
Chung-Ang University
|
| Department |
Life Science
|
| Lab |
Genome Dynamics Lab
|
| Street address |
84 Heuksuk-ro Dongjak-ku
|
| City |
Seoul |
| ZIP/Postal code |
06974 |
| Country |
South Korea |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA782650 |
| SRA |
SRP347289 |
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