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Series GSE189361 Query DataSets for GSE189361
Status Public on Nov 21, 2023
Title Self-assembled hyaluronic acid nanomedicine as a topical therapeutic agent for targeted modulation of dysregulated skin barrier and immune responses in a mouse model of psoriasis
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Purpose: profiling the differential transcripts usage in HACN treated macrophage polarization toward proinflammatory M1 polarization
Methods: transcriptome analysis by the RNA-seq via mRNA pull-down
Results: The mRNA profiles by RNA sequencing in bone marrow-derived macrophages showed that the whole gene expression patterns altered by lipopolysaccharide (LPS) were restored by HACN pre-treatment, and most of those genes were related to the inflammatory response including M1 polarization
Conclusions: The inhibitory effects of HA-NPs on LPS-induced M1 polarization are attributed to the presence of self-assembled HA shell, not the hydrophobic constituents and the free HAs.
Overall design N: control group, P: LPS treaed group, X LPS+HACA treated group
Contributor(s) Kim W, Kim J
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Submission date Nov 22, 2021
Last update date Nov 21, 2023
Contact name Jung-Woong Kim
Organization name Chung-Ang University
Department Life Science
Lab Genome Dynamics Lab
Street address 84 Heuksuk-ro Dongjak-ku
City Seoul
ZIP/Postal code 06974
Country South Korea
Platforms (1)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
Samples (6)
GSM5699921 N_1
GSM5699922 N_2
GSM5699923 P_1
BioProject PRJNA782650
SRA SRP347289

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189361_normalized_counts.txt.gz 3.0 Mb (ftp)(http) TXT
GSE189361_raw_counts.txt.gz 825.5 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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