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| Status |
Public on Jun 07, 2023 |
| Title |
Role of HNF4a in bone |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNAseq of osteocyte and osteoblasts enriched bone fraction from the tibiae of 6 week-old male mice with a conditional deletion of Hnf4a in osteoblasts and and WT littermates.
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| Overall design |
Hnf4αflox/+ (B6.129X1(FVB)-Hnf4αtm1.1Gonz/J) and osteocalcin-Cre (B6.FVB-Tg(BGLAP-cre)1Clem/J) mice were crossed to generate Hnf4αflox/flox (WT) and Hnf4αflox/flox-Cre (Hnf4αcKO). At 6 weeks, mice were sacrificed, and tibiae were excised, epiphyses removed and bone marrow flushed. Total RNA was isolated and submitted for RNAsequencing.
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| |
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| Contributor(s) |
David V, Martin A, Martinez Calle M |
| Citation(s) |
37079387 |
| |
| Submission date |
Dec 06, 2021 |
| Last update date |
Jun 07, 2023 |
| Contact name |
Valentin David |
| E-mail(s) |
valentin.david@northwestern.edu
|
| Phone |
13125034159
|
| Organization name |
Northwestern University
|
| Department |
Medicine
|
| Lab |
David Lab
|
| Street address |
320 E Superior Street
|
| City |
Chicago |
| State/province |
Illinois |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA786626 |
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