|
| Status |
Public on Jan 30, 2023 |
| Title |
Signalling inhibition by ponatinib disrupts alternative lengthening of telomeres (ALT) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Analyses of gene expression changes in cells treated with ponatinib (experiment 1), and in cells either lacking JUN or overexpressing JUN (experiment 2).
|
| |
|
| Overall design |
Experiment 1: RNA-seq on SAOS-2 or T1000 cells treated with either DMSO (as a control) or ponatinib (250nM for 24 hours); 2 replicates per condition. Experiment 2: Identification of potential JUN transcription targets by RNA-seq in SAOS2 cells lacking JUN (cjun sg vs. LacZ sg as a control) or overexpressing JUN (JUN vs. CTRL (GFP overexpressing cells)); 3 replicates per condition
|
| |
|
| Contributor(s) |
Jeitany M |
| Citation(s) |
37024489 |
| |
| Submission date |
Dec 08, 2021 |
| Last update date |
Apr 11, 2023 |
| Contact name |
Maya Jeitany |
| E-mail(s) |
maya.jeitany@gmail.com
|
| Organization name |
Nanyang Technological University
|
| Street address |
60 Nanyang Dr
|
| City |
Singapore |
| ZIP/Postal code |
637551 |
| Country |
Singapore |
| |
|
| Platforms (2) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (20)
|
|
| Relations |
| BioProject |
PRJNA787207 |
| SRA |
SRP349796 |
Less...
More...