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| Status |
Public on Dec 01, 2023 |
| Title |
RNA-Sequencing of rats treated with Chinese herbal medicine Pulsatilla Chinensis |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Pulsatilla chinensis (PC) is a traditional Chinese medicinewith detoxification activities. It has been used for dysentery, vaginal trichomoniasis, bacterial infections and malignant tumor treatment. Gavage administration of PC in hyperlipidemia rats for 11 weeks resulted in obviously reduced serum total cholesterol, LDL-cholesterol and ameliorated fatty liver. So we wanted to further investigate the relationship between PC and lipid metabolism related pathways or genes
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| Overall design |
Analysis used normal diet treated rats as control samples for comparison to the model samples treated with high cholesterol-high fat diet ,and the treatment group with high cholesterol-high fat diet plus Pulsatilla Chinensis for comparison to the model samples treated with high cholesterol-high fat diet , genes expression changes were determined by RNA-Seq to determine Pulsatilla Chinensis responsive genes
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| Contributor(s) |
Wang RJ, Xie L, Feng J, Zhang XL |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Dec 10, 2021 |
| Last update date |
Dec 01, 2023 |
| Contact name |
ruijun wang |
| E-mail(s) |
W841684901@126.com
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| Phone |
18518157361
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| Organization name |
Tsinghua university
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| Street address |
college of life science
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| City |
beijing |
| ZIP/Postal code |
102206 |
| Country |
China |
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| Platforms (1) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE190631 |
RNA-Sequencing of HepG2 cells and rats treated with Chinese herbal medicine Pulsatilla Chinensis |
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| Relations |
| BioProject |
PRJNA787819 |
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