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Series GSE190756 Query DataSets for GSE190756
Status Public on May 18, 2022
Title Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation
Organisms Blarina brevicauda; Marmota monax; Tamiasciurus hudsonicus; Mesocricetus auratus; Peromyscus maniculatus; Ondatra zibethicus; Mus musculus; Rattus rattus; Cavia porcellus; Hydrochoerus hydrochaeris; Myocastor coypus; Octodon degus; Heterocephalus glaber; Sciurus carolinensis; Chinchilla lanigera; Ellobius lutescens; Tamias striatus; Castor canadensis; Acomys russatus; Scalopus aquaticus; Neotoma cinerea; Cuniculus paca; Condylura cristata; Cricetulus barabensis; Fukomys damarensis
Experiment type Expression profiling by high throughput sequencing
Summary Mammals differ more than 100-fold in maximum lifespan. Here, we conducted comparative transcriptomics on 26 species with diverse lifespans. We identified thousands of genes with expression levels negatively or positively correlated with a species' maximum lifespan (Neg- or Pos-MLS genes). Neg-MLS genes are primarily involved in energy metabolism and inflammation. Pos-MLS genes show enrichment in DNA repair, microtubule organization, and RNA transport. Expression of Neg- and Pos-MLS genes is modulated by interventions, including mTOR and PI3K inhibition. Regulatory networks analysis showed that Neg-MLS genes are under circadian regulation possibly to avoid persistent high expression, whereas Pos-MLS genes are targets of master pluripotency regulators OCT4 and NANOG and are upregulated during somatic cell reprogramming. Pos-MLS genes are highly expressed during embryogenesis but significantly downregulated after birth. This work provides targets for anti-aging interventions by defining pathways correlating with longevity across mammals and uncovering circadian and pluripotency networks as central regulators of longevity.
 
Overall design Examination of gene expression across species.
 
Contributor(s) Lu JY, Gorbunova V, Seluanov A
Citation(s) 35580607, 38052795
Submission date Dec 13, 2021
Last update date Dec 14, 2023
Contact name jinlong lu
E-mail(s) bioyuyang@hotmail.com
Phone 5853098469
Organization name University of Rochester
Lab Gorbunova & Seluanov Labs
Street address 213 Hutchinson Hall
City Rochester
State/province NY
ZIP/Postal code 14627
Country USA
 
Platforms (25)
GPL21626 NextSeq 550 (Mus musculus)
GPL26915 NextSeq 550 (Cavia porcellus)
GPL29592 NextSeq 550 (Mesocricetus auratus)
Samples (522)
GSM5730459 AMS1Lung
GSM5730460 ASM1Brain
GSM5730461 ASM1Heart
Relations
BioProject PRJNA788430
SRA SRP350516

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE190756_RAW.tar 76.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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