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| Status |
Public on Aug 13, 2022 |
| Title |
Effect of FOXA2 knockout (KO) on transcriptome wide gene expression in hepatic progenitors (HP) and mature hepatocytes (MH) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
iPSC generated from healthy controls and FOXA2 knockout (KO) were allowed to undergo hepatic differentiation, and RNA was collected from hepatic progenitors (DAY 10) and mature hepatocytes (DAY21) for next-generation sequencing.
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| Overall design |
Transcriptomic profile of FOXA2 KO iPSCs - derived progenitors and mature hepatocytes was compared with healthy control from two biological replicates.
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| Contributor(s) |
Aghadi M, Elgendy R, Abdelalim E |
| Citation(s) |
35973994 |
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| Submission date |
Dec 13, 2021 |
| Last update date |
Aug 26, 2022 |
| Contact name |
Ramy Elgendy |
| E-mail(s) |
ramy.elgendy@astrazeneca.com
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| Organization name |
AstraZeneca
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| Street address |
Pepparedsleden 1
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| City |
Mölndal |
| State/province |
Göteborg |
| ZIP/Postal code |
43153 |
| Country |
Sweden |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (8)
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| GSM5731240 |
FOXA2 KO, Mature Hepatocytes, Samp12 |
| GSM5731241 |
FOXA2 KO, Hepatic Progenitor, HP1 |
| GSM5731242 |
FOXA2 KO, Hepatic Progenitor, HP3 |
| GSM5731243 |
FOXA2 WT, Mature Hepatocytes, Samp9 |
| GSM5731244 |
FOXA2 WT, Mature Hepatocytes, Samp11 |
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| Relations |
| BioProject |
PRJNA788448 |
| SRA |
SRP350523 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE190763_RAW.tar |
1.6 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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