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Status |
Public on Aug 13, 2022 |
Title |
Effect of FOXA2 knockout (KO) on transcriptome wide gene expression in hepatic progenitors (HP) and mature hepatocytes (MH) |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
iPSC generated from healthy controls and FOXA2 knockout (KO) were allowed to undergo hepatic differentiation, and RNA was collected from hepatic progenitors (DAY 10) and mature hepatocytes (DAY21) for next-generation sequencing.
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Overall design |
Transcriptomic profile of FOXA2 KO iPSCs - derived progenitors and mature hepatocytes was compared with healthy control from two biological replicates.
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Contributor(s) |
Aghadi M, Elgendy R, Abdelalim E |
Citation(s) |
35973994 |
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Submission date |
Dec 13, 2021 |
Last update date |
Aug 26, 2022 |
Contact name |
Ramy Elgendy |
E-mail(s) |
ramy.elgendy@astrazeneca.com
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Organization name |
AstraZeneca
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Street address |
Pepparedsleden 1
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City |
Mölndal |
State/province |
Göteborg |
ZIP/Postal code |
43153 |
Country |
Sweden |
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Platforms (1) |
GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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Samples (8)
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GSM5731240 |
FOXA2 KO, Mature Hepatocytes, Samp12 |
GSM5731241 |
FOXA2 KO, Hepatic Progenitor, HP1 |
GSM5731242 |
FOXA2 KO, Hepatic Progenitor, HP3 |
GSM5731243 |
FOXA2 WT, Mature Hepatocytes, Samp9 |
GSM5731244 |
FOXA2 WT, Mature Hepatocytes, Samp11 |
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Relations |
BioProject |
PRJNA788448 |
SRA |
SRP350523 |
Supplementary file |
Size |
Download |
File type/resource |
GSE190763_RAW.tar |
1.6 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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