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| Status |
Public on Dec 01, 2023 |
| Title |
In situ Growth of ZIF-8 Nanoparticles on Graphene Oxide Nanosheets: A Multifunctional Nanoplatform for Combined Ionâinterference and Photothermal Therapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In summary, highly stability and dispersed BSArGO@ZIF8 NSs were prepared by a simple electrostatic interaction method. According to the delivery effect of BSArGO@ZIF8 NSs, we found that BSArGO@ZIF8 NSs possess higher lethality to cancer cells. Furthermore, under NIR irradiation, BSArGO@ZIF8 NSs-mediated PTT could further kill cancer cells, and the increased temperature caused by photothermal conversion accelerated the Fenton reaction rate, enhancing the efficiency of BSArGO@ZIF8 NSs cell lethality. RNA-seq analysis confirmed that. BSArGO@ZIF8 NSs could promote cancer death through activate bim-mediated mitochondrial apoptotic events, induce disruption of microtubule function, loss of integrity of the nuclear membrane, DNA flagmentation, and change pro-apoptptic genes expression.
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| Overall design |
Total RNA of Cal27 from 3 different experiments treated with or without BSArGO@ZIF-8 NSs at 6 h were collected and RNA-seq was used to analyze the whole genome expression at LC Sciences through the Illumina X10 platform
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| Contributor(s) |
Ma B, Kang W |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Dec 17, 2021 |
| Last update date |
Dec 01, 2023 |
| Contact name |
Wenyan Kang |
| E-mail(s) |
202090000024@sdu.edu.cn
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| Organization name |
Shandong university
|
| Street address |
No. 44-1 Wenhua Road West
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| City |
Jinan, Shandong |
| ZIP/Postal code |
250012 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA789922 |
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