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| Status |
Public on Dec 20, 2021 |
| Title |
Gene expression analysis of astrocytes differentiated from iPS cells generated from monozygotic twins discordant for schizophrenia |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Previous studies have implicated several brain cell types in schizophrenia, but the genetic impact of astrocytes is unknown. Considering their high complexity in humans, astrocytes are likely key determinants of neurodevelopmental diseases. Human induced pluripotent stem cell (hiPSC) -derived astrocytes differentiated from five monozygotic twin pairs discordant for schizophrenia and five healthy subjects were studied for alterations related to high genetic risk and clinical manifestation of SCZ in astrocyte transcriptomics.
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| Overall design |
Ribo-depleted RNA was sequenced with Illumina Next-seq 500 from iPS derived astrocytes
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| Contributor(s) |
Koistinaho J, Tiihonen J |
| Citation(s) |
34936134 |
| |
| Submission date |
Dec 20, 2021 |
| Last update date |
Mar 28, 2022 |
| Contact name |
Iiris Hovatta |
| E-mail(s) |
iiris.hovatta@helsinki.fi
|
| Organization name |
University of Helsinki
|
| Department |
Department of Psychology and Logopedics
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| Lab |
Neurogenomics
|
| Street address |
Haartmaninkatu 3
|
| City |
Helsinki |
| ZIP/Postal code |
00014 |
| Country |
Finland |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE191250 |
Contribution of astrocytes to familial risk and clinical manifestation of Schizophrenia |
|
| Relations |
| BioProject |
PRJNA790755 |
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