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Status |
Public on Mar 01, 2022 |
Title |
Whole blood DNA methylation arrays of individuals with Sotos syndrome and healthy control subjects |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by array
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Summary |
To understand how NSD1 inactivation deregulates DNA methylation, and to explore how these abnormalities affect human development, we profiled DNA methylation in SS patients and healthy control individuals using the Illumina Infinium EPIC Beadchip array.
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Overall design |
Genome-wide DNA methylation was profiled in whole blood samples of three individuals with Sotos syndrome (n=3), and age- and sex-matched healthy control subjects (n=3). Control subjects represent anonymous blood donors that were matched to probands by age and sex. We also profiled a pooled blood DNA sample of the unaffected parents of the three probands (n=5 parents).
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Contributor(s) |
Brennan K, Gevaert O |
Citation(s) |
35094088 |
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Submission date |
Dec 20, 2021 |
Last update date |
May 31, 2022 |
Contact name |
Caroline Dive |
E-mail(s) |
caroline.dive@cruk.manchester.ac.uk
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Organization name |
Cancer Research UK Manchester Institute
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Street address |
Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road
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City |
Manchester |
ZIP/Postal code |
M20 4BX |
Country |
United Kingdom |
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Platforms (1) |
GPL23976 |
Illumina Infinium HumanMethylation850 BeadChip |
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Samples (7)
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This SubSeries is part of SuperSeries: |
GSE191277 |
Sotos syndrome and healthy control subjects |
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Relations |
BioProject |
PRJNA790839 |