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Status |
Public on Jul 26, 2022 |
Title |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease [methylation] |
Organism |
Homo sapiens |
Experiment type |
Methylation profiling by genome tiling array
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Summary |
We investigated the dynamics of DNA methylation in blood samples of IBD patients treated with infliximab and analyzed the predictive potential regarding therapy outcome.
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Overall design |
We performed a longitudinal, blood-based multi-omics study in two prospective IBD patient cohorts receiving first time infliximab therapy (discovery: 14 patients, replication: 23 patients). Samples were collected at up to 7 timepoints (from baseline to 14 weeks after therapy induction).
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Contributor(s) |
Mishra N, Aden K, Baran N, Rosentiel P |
Citation(s) |
36153599 |
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Submission date |
Dec 20, 2021 |
Last update date |
Oct 24, 2022 |
Contact name |
Neha Mishra |
E-mail(s) |
n.mishra@ikmb.uni-kiel.de
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Organization name |
Institute of Clinical Molecular Biology
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Lab |
Cell biology Lab
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Street address |
Rosalind-Franklin-Str. 12
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City |
Kiel |
ZIP/Postal code |
24105 |
Country |
Germany |
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Platforms (1) |
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Samples (85)
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This SubSeries is part of SuperSeries: |
GSE191331 |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease |
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Relations |
BioProject |
PRJNA790984 |