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| Status |
Public on Jul 26, 2022 |
| Title |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease [methylation] |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by genome tiling array
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| Summary |
We investigated the dynamics of DNA methylation in blood samples of IBD patients treated with infliximab and analyzed the predictive potential regarding therapy outcome.
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| Overall design |
We performed a longitudinal, blood-based multi-omics study in two prospective IBD patient cohorts receiving first time infliximab therapy (discovery: 14 patients, replication: 23 patients). Samples were collected at up to 7 timepoints (from baseline to 14 weeks after therapy induction).
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| Contributor(s) |
Mishra N, Aden K, Baran N, Rosentiel P |
| Citation(s) |
36153599 |
| |
| Submission date |
Dec 20, 2021 |
| Last update date |
Oct 24, 2022 |
| Contact name |
Neha Mishra |
| E-mail(s) |
n.mishra@ikmb.uni-kiel.de
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| Organization name |
Institute of Clinical Molecular Biology
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| Lab |
Cell biology Lab
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| Street address |
Rosalind-Franklin-Str. 12
|
| City |
Kiel |
| ZIP/Postal code |
24105 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (85)
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| This SubSeries is part of SuperSeries: |
| GSE191331 |
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease |
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| Relations |
| BioProject |
PRJNA790984 |
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