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Status |
Public on Dec 01, 2009 |
Title |
SNP data from 20 bladder tumors |
Organism |
Homo sapiens |
Experiment type |
Genome variation profiling by SNP array
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Summary |
We present the first computational approach to reconstruct the sequence of copy number alterations driving carcinogenesis from the analysis of several tumor samples of a same patient. Applied to BAC array-CGH and SNP array data from bladder and breast cancers, this method proved highly valuable to establish the clonal relationships between primary tumors and recurrences and to identify the chromosome aberrations at the initiation of tumorigenesis.
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Overall design |
An algorithm was developed to reconstruct tumors lineage and the sequence of copy number alterations along tumorigenesis from the analysis of several samples from a same patient. The data here consist in Illumina SNP data from 20 bladder tumors. 15 of these tumors (REF1 to REF15) come from independent samples and were used to compute the frequencies of breakpoints at each location. The 5 other samples (S4_A, S4_B, S5_A, S5_B, and S5_C) are multiple tumors from 2 patients. They were used to reconstruct the sequence of chromosome aberrations along cancer development in these 2 patients.
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Contributor(s) |
Allory Y, Letouzé E, Radvanyi F |
Citation(s) |
20649963 |
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Submission date |
Nov 25, 2009 |
Last update date |
Jan 30, 2015 |
Contact name |
Eric Letouzé |
E-mail(s) |
Eric.letouze@inserm.fr
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Organization name |
Ligue Contre Le Cancer
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Lab |
Centre de Recherche des Cordeliers
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Street address |
15 rue de l'école de médecine
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City |
Paris |
ZIP/Postal code |
75006 |
Country |
France |
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Platforms (1) |
GPL6985 |
Illumina HumanCNV370-QuadV3 DNA Analysis BeadChip (HumanCNV370-QuadV3_C) |
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Samples (20)
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This SubSeries is part of SuperSeries: |
GSE19195 |
Analysis of copy number profiles of several tumor samples of same patient reveals the successive steps in tumorigenesis |
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Relations |
BioProject |
PRJNA123745 |