|
| Status |
Public on Nov 26, 2009 |
| Title |
PML-RARa binding sites and their correlation with the gene expression in ATRA treated NB4 cells |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
Expression profiling by array
|
| Summary |
PML-RARa contributes to the development of APL through repression of genes important in myeloid development. Through a global approach, we have identified 2,979 high quality PML-RARa binding sites in ZnSO4 induced PR9 cells. By integration the gene expression data, we found that PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in ATRA treated NB4 cells.
This SuperSeries is composed of the SubSeries listed below.
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| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
20159610 |
| |
| Submission date |
Nov 25, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jiantao Shi |
| E-mail(s) |
jtshi@sibs.ac.cn
|
| Organization name |
Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine (RJH-SJTU-SM)
|
| Street address |
197 Ruijin Rd II
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
| |
|
| Platforms (2) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
| GPL5082 |
[Hs_PromPR] Affymetrix Human Promoter 1.0R Array |
|
| Samples (7)
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| This SuperSeries is composed of the following SubSeries: |
| GSE19201 |
Expression profiling of ATRA treated NB4 cells |
| GSE19202 |
Genome-wide recognition of PML/RARa binding sites |
|
| Relations |
| BioProject |
PRJNA120809 |
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