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Series GSE19203 Query DataSets for GSE19203
Status Public on Nov 26, 2009
Title PML-RARa binding sites and their correlation with the gene expression in ATRA treated NB4 cells
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by genome tiling array
Expression profiling by array
Summary PML-RARa contributes to the development of APL through repression of genes important in myeloid development. Through a global approach, we have identified 2,979 high quality PML-RARa binding sites in ZnSO4 induced PR9 cells. By integration the gene expression data, we found that PML/RARa target genes are transcriptionally suppressed in primary APL cells and re-activated in ATRA treated NB4 cells.

This SuperSeries is composed of the SubSeries listed below.
Overall design Refer to individual Series
Citation(s) 20159610
Submission date Nov 25, 2009
Last update date Mar 25, 2019
Contact name Jiantao Shi
Organization name Rui-Jin Hospital affiliated to Shanghai Jiao Tong University School of Medicine (RJH-SJTU-SM)
Street address 197 Ruijin Rd II
City Shanghai
State/province Shanghai
ZIP/Postal code 200025
Country China
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL5082 [Hs_PromPR] Affymetrix Human Promoter 1.0R Array
Samples (7)
GSM475993 Un-treated NB4 cells
GSM475994 ATRA treated NB4 cells, 4 hours
GSM475995 ATRA treated NB4 cells, 12 hours
This SuperSeries is composed of the following SubSeries:
GSE19201 Expression profiling of ATRA treated NB4 cells
GSE19202 Genome-wide recognition of PML/RARa binding sites
BioProject PRJNA120809

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19203_RAW.tar 189.0 Mb (http)(custom) TAR (of BAR, BED, CEL, TXT)
Processed data included within Sample table
Processed data provided as supplementary file
Raw data provided as supplementary file

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