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Series GSE192647 Query DataSets for GSE192647
Status Public on May 22, 2024
Title Transcriptome analysis of pancreatic cancer patients with low and high metabolic tumor volume (MTV)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Transcriptome wide-comparison between MTV-low and -high groups was performed with three types: 1) cancer to normal site ratio, cancer site, and normal site. Among three types of comparison, the cancer-to-normal site ratio was the most informative. 211 genes were generally upregulated, and 166 genes were downregulated in the MTV-high group compared to the MTV-low group. Of 211 upregulated gens, 44 showed more than a 2-fold difference and statistical significance. On the other hand, of 166 downregulated genes, 56 showed more than a 2-fold difference and statistical significance. In functional annotation analysis, the GO terms of the upregulated genes were enriched to Wnt signaling (GO: 0035567, 0060070, 0060071), sister chromatid cohesion (GO: 0007062), and cell division (GO: 0000278, 0051301) trends (Figure 1E-a), whereas those of the downregulated genes were enriched to rRNA processing (GO: 0006364), translation (GO: 0006412, 0006413), nuclear-transcribed mRNA catabolic process (GO: 0000184) trends (Figure 1E-b). 28 upregulated genes belonged to Wnt signaling or Cell division, while 22 downregulated genes belonged to rRNA processing.
 
Overall design Pancreatic cancer patients were classified into low MTV and high MTV groups by 18F-FDG PET/CT scan, and their post-resected tissues were used for total RNA-Seq.
 
Contributor(s) Kim BG, Lee SH, Jang Y, Kang S, Kang CM, Cho NH
Citation(s) 38741142
Submission date Dec 27, 2021
Last update date May 23, 2024
Contact name Baek Gil Kim
E-mail(s) bbaekiri@hanmail.net
Organization name Yonsei University
Street address 50-1 Yonsei-Ro
City Seoul
ZIP/Postal code 03722
Country South Korea
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (28)
GSM5753946 MTV-low patient #1_normal
GSM5753947 MTV-low patient #1_cancer
GSM5753948 MTV-low patient #2_normal
Relations
BioProject PRJNA792551

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE192647_RAW.tar 11.0 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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