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Status |
Public on May 22, 2024 |
Title |
Transcriptome analysis of pancreatic cancer patients with low and high metabolic tumor volume (MTV) |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
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Summary |
Transcriptome wide-comparison between MTV-low and -high groups was performed with three types: 1) cancer to normal site ratio, cancer site, and normal site. Among three types of comparison, the cancer-to-normal site ratio was the most informative. 211 genes were generally upregulated, and 166 genes were downregulated in the MTV-high group compared to the MTV-low group. Of 211 upregulated gens, 44 showed more than a 2-fold difference and statistical significance. On the other hand, of 166 downregulated genes, 56 showed more than a 2-fold difference and statistical significance. In functional annotation analysis, the GO terms of the upregulated genes were enriched to Wnt signaling (GO: 0035567, 0060070, 0060071), sister chromatid cohesion (GO: 0007062), and cell division (GO: 0000278, 0051301) trends (Figure 1E-a), whereas those of the downregulated genes were enriched to rRNA processing (GO: 0006364), translation (GO: 0006412, 0006413), nuclear-transcribed mRNA catabolic process (GO: 0000184) trends (Figure 1E-b). 28 upregulated genes belonged to Wnt signaling or Cell division, while 22 downregulated genes belonged to rRNA processing.
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Overall design |
Pancreatic cancer patients were classified into low MTV and high MTV groups by 18F-FDG PET/CT scan, and their post-resected tissues were used for total RNA-Seq.
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Contributor(s) |
Kim BG, Lee SH, Jang Y, Kang S, Kang CM, Cho NH |
Citation(s) |
38741142 |
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Submission date |
Dec 27, 2021 |
Last update date |
May 23, 2024 |
Contact name |
Baek Gil Kim |
E-mail(s) |
bbaekiri@hanmail.net
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Organization name |
Yonsei University
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Street address |
50-1 Yonsei-Ro
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City |
Seoul |
ZIP/Postal code |
03722 |
Country |
South Korea |
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Platforms (1) |
GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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Samples (28)
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Relations |
BioProject |
PRJNA792551 |
Supplementary file |
Size |
Download |
File type/resource |
GSE192647_RAW.tar |
11.0 Mb |
(http)(custom) |
TAR (of TXT) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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