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Series GSE192726 Query DataSets for GSE192726
Status Public on Oct 01, 2023
Title Differenatiation of mRNA expression in PTX3-depleted macrophages
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary PTX3, as the long member of the pentraxin family, is produced mainly by dendritic cells, macrophages, and endothelial cells in response to inflammation. Growing amount of studies suggest that PTX3 can exert potential contradictory roles in inflammation regulation, antimicrobial resistance, and disease pathogenesis, depending on the tissue context, cellular source, and levels of production. To characterize the potential involvement of PTX3 in macrophage function, transcriptome sequencing (RNA-seq) was performed in human THP1-derived macrophages with PTX3 depletion. Notably,genes enrichment in PI3K/AKT signaling , JAK/STAT signaling and autophagy pathway were observed in PTX3 deficiency macrophages. This study highlights the critical roles of PTX3 on regulation macrophages homeostasis.
 
Overall design The mRNA profiles of WT and PTX3-depleted macrophages under IL-4 stimulation. Three independent experiments were performed at each treatment.
 
Contributor(s) Han X, Xiao W
Citation(s) 37957139
Submission date Dec 29, 2021
Last update date Dec 07, 2023
Contact name Xiao Han
E-mail(s) sqhx12@126.com
Phone 02164932897
Organization name Children’s Hospital of Fudan University
Street address 399 Wanyuan Rd, Minhang, Shanghai, China
City Shanghai
State/province Select state...
ZIP/Postal code 201102
Country China
 
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM5763676 THP1-derived macrophages, siNC-1
GSM5763677 THP1-derived macrophages, siNC-2
GSM5763678 THP1-derived macrophages, siNC-3
Relations
BioProject PRJNA792950

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE192726_siPTX3_Processed_data.xlsx 2.2 Mb (ftp)(http) XLSX
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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