NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE19276 Query DataSets for GSE19276
Status Public on Jan 31, 2010
Title Osteosarcoma is characterized by impaired osteoclastogenesis and antigen presentation compared to normal bone
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Osteosarcoma is characterized by reduced expression of markers of impaired osteoclastogenesis and antigen presentation compared to normal bone
Osteosarcoma (OS) is the most common primary bone tumour in children and young adults, and the second highest cause of cancer-related death in this age group. In spite of aggressive chemotherapy, disease-free survival has not improved significantly in the past 20 years, and 50% of patients subsequently develop fatal pulmonary metastasis. We have performed gene expression profiling of primary osteosarcoma biopsies and compared the results to gene expression profiling of non-malignant bone to identify differentially expressed genes unique to OS in the context of the bone micorenvironment.

Keywords: Comaprison between disease status (OS) and normal; comparison between good and poor response to chemotherapy
 
Overall design Two-colour experiment. 23 samples of OS analyzed in duplicate (dye-swaps); 3 samples of good responders, 20 of poor responders analyzed in duplicate (dye-swaps); 5 samples of non-malignant bone analyzed individualy, no dye-swaps (i.e. 5 biological replicates).
 
Contributor(s) Endo-Munoz LB, Cumming A, Sommerville S, Dickinson I, Saunders NA
Citation(s)
  • Endo-Munoz L, Cumming A, Sommerville S, Dickinson I et al. Osteosarcoma is characterised by reduced expression of markers of osteoclastogenesis and antigen presentation compared with normal bone. Br J Cancer 2010 Jun 29;103(1):73-81. PMID: 20551950
Submission date Dec 02, 2009
Last update date Sep 01, 2015
Contact name Liliana Beatriz Endo-Munoz
E-mail(s) l.munoz@uq.edu.au
Phone +61734436929
Organization name University of Queensland
Department Diamantina Institute
Lab Saunders
Street address TRI, 37 Kent St
City Woolloongabba
State/province Queensland
ZIP/Postal code 4102
Country Australia
 
Platforms (1)
GPL6848 Agilent-012391 Whole Human Genome Oligo Microarray G4112A (Probe Name version)
Samples (49)
GSM481071 OSN1 A Biopsy_poor_rep 1
GSM481072 OSN1 B Biopsy_poor_dye-swap_rep 2
GSM481073 OSN2 A Biopsy_poor_rep 1
Relations
BioProject PRJNA120957

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19276_RAW.tar 428.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.