 |
 |
GEO help: Mouse over screen elements for information. |
|
| Status |
Public on Jan 05, 2022 |
| Title |
Transcriptomic Analysis of Rat Cerebral Cortex Reveals the Potential Mechanism of Electroacupuncture Opening Blood Brain Barrier |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Therapeutic treatment options for central nervous system (CNS) diseases are greatly limited by the blood-brain barrier (BBB). Electroacupuncture (EA) can be used to induce an increase in BBB permeability on rats, providing a potential approach for the delivery of drugs from the systemic circulation into the brain. However, there remains a large gap in our knowledge regarding the impact of EA on brain gene expression. This work is focused on investigating the transcriptional changes of rat cerebral cortex following EA and expression changes in genes and bioinformatic analysis was performed. Our results provide a valuable resource that will guide mechanism research of EA opening BBB and other ways to mediate drug delivery into the brain.
|
| |
|
| Overall design |
This work is focused on investigating the transcriptional changes of rat cerebral cortex following EA and expression changes in genes and bioinformatic analysis was performed.
|
| |
|
| Contributor(s) |
Ma C, Lin X |
| Citation(s) |
35281512 |
| Submission date |
Jan 02, 2022 |
| Last update date |
Nov 08, 2023 |
| Contact name |
Congcong Ma |
| E-mail(s) |
202011011211043@zcmu.cn
|
| Phone |
18745752108
|
| Organization name |
Zhejiang Chinese Medical University
|
| Street address |
No. 548, binwen Road
|
| City |
Hangzhou |
| ZIP/Postal code |
310053 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
|
| Samples (10)
|
| GSM5767956 |
Cerebral cortex, control, 4 |
| GSM5767957 |
Cerebral cortex, control, 5 |
| GSM5767958 |
Cerebral cortex, EA, 1 |
| GSM5767959 |
Cerebral cortex, EA, 2 |
| GSM5767960 |
Cerebral cortex, EA, 3 |
| GSM5767961 |
Cerebral cortex, EA, 4 |
| GSM5767962 |
Cerebral cortex, EA, 5 |
|
| Relations |
| BioProject |
PRJNA793677 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE192885_4_genes_fpkm_expression.txt.gz |
5.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
|
|
|
|
 |
Less...
More...