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Series GSE192959 Query DataSets for GSE192959
Status Public on Jul 01, 2022
Title Transcriptome profile of liver biopsy tissues from patients with non-alcoholic fatty liver disease (derivation set).
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with its high prevalence and risk of developing lethal complications, progressive liver fibrosis and hepatocellular carcinoma (HCC), the only rising cancer mortality in the U.S. For early HCC detection to improve the dismal prognosis, there is an urgent unmet need to identify a subset of NAFLD patients with elevated risk of HCC. Herein, we derived a hepatic-transcriptome-based NAFLD-specific HCC risk biomarker, PLS-NAFLD, and validated it in two independent cohorts of HCC-naive and experienced NAFLD patients..
 
Overall design Liver biopsy tissues were obtained at the time of ablating NAFLD-related HCC tumors and subjected for RNA isolation and genome-wide transcriptome profiling with RNA-Seq.
 
Contributor(s) Fujiwara N, Zhu S, Hoshida Y
Citation(s) 35731891
Submission date Jan 03, 2022
Last update date Jul 01, 2022
Contact name Naoto Fujiwara
E-mail(s) naoto-fujiwara@med.mie-u.ac.jp
Organization name Mie University
Street address 2-174 Edobashi
City Tsu city
State/province Mie
ZIP/Postal code 514-8507
Country Japan
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (48)
GSM5769797 TUnafld001
GSM5769798 TUnafld003
GSM5769799 TUnafld004
This SubSeries is part of SuperSeries:
GSE193084 Transcriptome profile of liver biopsy tissues from patients with non-alcoholic fatty liver disease
Relations
BioProject PRJNA793895

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE192959_NAFLD.TUn48.gct.gz 3.9 Mb (ftp)(http) GCT
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Raw data are available in SRA
Processed data are available on Series record

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