NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE193356 Query DataSets for GSE193356
Status Public on Oct 19, 2022
Title The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry [4C-seq]
Organism Mus musculus
Experiment type Other
Summary Prdm1 encodes the transcriptional repressor PRDM1/BLIMP1 and Prdm1 mutant mice are one of the rare mutant strains that do not develop whisker hair follicles while still displaying a pelage. We demonstrate that Lef1, a key mediator of the Wnt/Beta Catenin pathway, acts upstream of Prdm1 and identify a primate specific deletion of a Lef1 enhancer, Leaf. This loss may have been significant in the evolutionary process, leading to the progressive defunctionalization and disappearance of vibrissae in primates.
 
Overall design 120 whisker pads from e12.5 embryos were microdissected and digested to a single cell suspension and processed with the 4C-Seq protocol per condition. The murine adult kidneys were used as control.
 
Contributor(s) Pierluigi M, Fabrice D, Marion L, Yann B
Citation(s) 36289911
Submission date Jan 10, 2022
Last update date Nov 02, 2022
Contact name Pierluigi Giuseppe Manti
E-mail(s) pierluigigiuseppe.manti@gmail.com
Organization name University of Milan
Street address Via Festa del Perdono 7
City Milan
ZIP/Postal code 20122
Country Italy
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM5795896 whisker pad e12.5 4C-Seq Lef1
GSM5795897 whisker pad e12.5 4C-Seq Leaf
GSM5795898 adult kidney 4C-Seq Lef1
This SubSeries is part of SuperSeries:
GSE193357 The transcriptional regulator Prdm1 is a master gene for the early development of the sensory whisker follicle and is wired to the Lef1 circuitry.
Relations
BioProject PRJNA795955

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE193356_RAW.tar 14.2 Mb (http)(custom) TAR (of BEDGRAPH)
GSE193356_table_raw_and_rawSmoothed.txt.gz 19.0 Mb (ftp)(http) TXT
GSE193356_track_normMedianTADreg.tar.gz 71.5 Kb (ftp)(http) TAR
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap
External link. Please review our privacy policy.