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| Status |
Public on Jan 13, 2022 |
| Title |
The transcription factor Zfp335 promotes differentiation and persistence of memory CD8+ T cells by regulating TCF-1 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Memory CD8+ T cells play an essential role in providing effective and lifelong protection against pathogens. Comprehensive transcriptional and epigenetic networks are involved in modulating memory T cell development, but the molecular regulations of CD8+ memory T cell formation and long-term persistence remain largely unknown. Here, we show that zinc finger protein 335 (Zfp335) is indispensable for CD8+ T cell memory establishment and maintenance during acute infections. Mice with Zfp335 deletion in CD8+ T cells exhibit a significant reduction of memory T cells and memory precursor cells in the contraction phase.
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| Overall design |
WT and KO CD8+ T cells were sorted from the spleens of recipient mice 7 days after LM-OVA infection in the co-transfer model.
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| Contributor(s) |
Zhang B, Liu H |
| Citation(s) |
35914836 |
| Submission date |
Jan 10, 2022 |
| Last update date |
Sep 21, 2022 |
| Contact name |
Cangang Zhang |
| E-mail(s) |
cg.zhang20195028@stu.xjtu.edu.cn
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| Phone |
13636810556
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| Organization name |
xian jiaotong university
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| Street address |
Yanta district, xi 'an city, shaanxi province
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| City |
xian |
| State/province |
State... |
| ZIP/Postal code |
710000 |
| Country |
China |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA795976 |
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