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Series GSE193427 Query DataSets for GSE193427
Status Public on Jan 16, 2023
Title Gain and/or amplification of chromosome 1q are frequently found in Multiple Myeloma (MM).
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Background: Gain and/or amplification of chromosome 1q are frequently found in Multiple Myeloma (MM). The number of 1q copies correlates with a poor prognosis. The aim of this work is to study the impact on the clinical outcome and the trascriptomic changes induced by Gain1q (3 copies of 1q, 3X) and amplification 1q (Amp1q, ≥4 copies of 1q, 4X) in MM patients enrolled in the CoMMpass study (NCT145429). Methods: Fluorescence in situ hybridization (FISH) in CD138+ purified bone marrow plasma cells was centralized and performed at baseline. The cut-off level for Gain1q was 10% of nuclei with ≥3 copies of 1q (3X), while Amp1q was defined as ≥ 20% of nuclei with ≥4 copies of 1q (4X). Transcriptome data from patients were used to find differentially expressed genes (DEGs) in gain (3X) and amp1q (4X) patients.
 
Overall design 24 samples, 8 with two copies of 1q (2X), 8 with three copies of 1q (3X) and 8 with four copies of 1q (4X)
 
Contributor(s) D'Agostino M, Gay F, Calogero RA
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Submission date Jan 11, 2022
Last update date Jan 16, 2023
Contact name Raffaele A Calogero
E-mail(s) raffaele.calogero@unito.it
Phone ++39 0116706454
Organization name University of Torino
Department Molecular Biotechnology Center
Lab Bioinformatics and Genomics Unit
Street address Via Nizza 52
City Torino
State/province To
ZIP/Postal code 10126
Country Italy
 
Platforms (1)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
Samples (24)
GSM5800098 two copies of 1q (2X) [60022c1q100]
GSM5800099 two copies of 1q (2X) [600327c1q100]
GSM5800100 two copies of 1q (2X) [600355c1q100]
Relations
BioProject PRJNA796206

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE193427_counts.txt.gz 945.2 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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