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| Status |
Public on May 20, 2022 |
| Title |
Taurocholate acid signals a specific gene expression reprogramming affecting amino-acids and nucleotides metabolisms |
| Organism |
Enterococcus faecalis |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Enterococcus faecalis is a natural inhabitant of the human gastrointestinal tract. In a healthy physiological state of the gut (eubiosis), E. faecalis is a subdominant species in the intestinal microbiota. When the intestinal homeostasis is disrupted (dysbiosis), it becomes dominant species and can cause infections. The taurocholate bile acid (TCA) becomes prominent during dysbiosis. This experiment aimed to better understand how E. faecalis adapts to TCA. We showed that TCA reprograms genes involved in the pool management of amino acids and nucleotides.
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| Overall design |
Impact of TCA on E. faecalis gene expression. Samples were sequenced at different time points after addition of 2 mM TCA (0.1% final).
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| Contributor(s) |
Repoila F, Le-Bohec F, Guérin C, Nicolas P |
| Citation(s) |
35590028 |
| |
| Submission date |
Jan 19, 2022 |
| Last update date |
May 26, 2022 |
| Contact name |
Cyprien Guérin |
| E-mail(s) |
cyprien.guerin@inrae.fr
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| Phone |
+33-1-3465-2896
|
| Organization name |
INRAE
|
| Lab |
MaIAGE
|
| Street address |
INRAE - Domaine de Vilvert
|
| City |
Jouy-en-Josas |
| ZIP/Postal code |
F-78350 |
| Country |
France |
| |
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| Platforms (1) |
| GPL23172 |
Illumina HiSeq 2500 (Enterococcus faecalis) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE194011 |
Contrasted effects of deoxycholate and taurocholate bile acids on the gut pathobiont Enterococcus faecalis |
|
| Relations |
| BioProject |
PRJNA798735 |
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