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Series GSE195714 Query DataSets for GSE195714
Status Public on Oct 19, 2022
Title Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis [ATAC-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The tumor suppressor LATS1, whose expression is often downregulated in human breast cancer, helps maintain luminal breast cancer cell identity by keeping basal-specific genes in a closed chromatin state, preventing their spurious activation. This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and recruitment of HDAC1,driving histone H3K27 deacetylation near NCOR1-repressed “basal” genes. Consequently, decreased expression of LATS1 elevates the expression of such “basal” genes and promotes luminal-to-basal slippage.
 
Overall design 4 samples X 2 replicates = 8 samples total
 
Contributor(s) Aylon Y, Furth N, Friedlander G, Oren M
Citation(s) 36443319
Submission date Jan 30, 2022
Last update date Dec 15, 2022
Contact name Yael Aylon
E-mail(s) yael.aylon@weizmann.ac.il
Organization name Weizmann Institute of Science
Department MCB
Lab Prof Moshe Oren
Street address 234 Herzl St
City Rehovot
ZIP/Postal code 7610001
Country Israel
 
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (8)
GSM5848727 WT luminal, BM1, ATAC-seq
GSM5848728 WT basal, BM2, ATAC-seq
GSM5848729 Lats1-CKO luminal, BM3, ATAC-seq
This SubSeries is part of SuperSeries:
GSE195716 Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis
Relations
BioProject PRJNA801933

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE195714_RAW.tar 6.5 Mb (http)(custom) TAR (of BED)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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