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Status |
Public on Oct 19, 2022 |
Title |
Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis [ATAC-seq] |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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Summary |
The tumor suppressor LATS1, whose expression is often downregulated in human breast cancer, helps maintain luminal breast cancer cell identity by keeping basal-specific genes in a closed chromatin state, preventing their spurious activation. This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and recruitment of HDAC1,driving histone H3K27 deacetylation near NCOR1-repressed “basal” genes. Consequently, decreased expression of LATS1 elevates the expression of such “basal” genes and promotes luminal-to-basal slippage.
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Overall design |
4 samples X 2 replicates = 8 samples total
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Contributor(s) |
Aylon Y, Furth N, Friedlander G, Oren M |
Citation(s) |
36443319 |
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Submission date |
Jan 30, 2022 |
Last update date |
Dec 15, 2022 |
Contact name |
Yael Aylon |
E-mail(s) |
yael.aylon@weizmann.ac.il
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Organization name |
Weizmann Institute of Science
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Department |
MCB
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Lab |
Prof Moshe Oren
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Street address |
234 Herzl St
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City |
Rehovot |
ZIP/Postal code |
7610001 |
Country |
Israel |
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Platforms (1) |
GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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Samples (8)
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GSM5848730 |
Lats1-CKO basal, BM4, ATAC-seq |
GSM5848731 |
WT luminal, BM5, ATAC-seq |
GSM5848732 |
WT basal, BM6, ATAC-seq |
GSM5848733 |
Lats1-CKO luminal, BM7, ATAC-seq |
GSM5848734 |
Lats1-CKO basal, BM8, ATAC-seq |
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This SubSeries is part of SuperSeries: |
GSE195716 |
Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis |
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Relations |
BioProject |
PRJNA801933 |
Supplementary file |
Size |
Download |
File type/resource |
GSE195714_RAW.tar |
6.5 Mb |
(http)(custom) |
TAR (of BED) |
SRA Run Selector |
Raw data are available in SRA |
Processed data provided as supplementary file |
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